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Abstract：
Introduction: The etiology of esophageal squamous papilloma (ESP) is largely unknown. Previous studies have shown a variable association with human papillomavirus (HPV) with conflicting data. The aim of this study was to further investigate the possible association of HPV in our ESP series using RNA in-situ hybridization (ISH) and compare study groups from the United States of America and China. Methods: Demographic and clinical data of patients with ESP were retrieved from the University of California Los Angeles (UCLA) (1/2016-3/2019) and Peking Union Medical College Hospital (PUMCH) (9/2014-3/2019) pathology databases. Hematoxylin and eosin slides were reexamined. Confirmed cases were examined by high- and low-risk HPV RNA ISH. Results: For the UCLA cohort, 13 429 upper endoscopies were performed and 78 biopsies from 72 patients were identified as ESP (F:M = 45:27, 66.7% > 45 years). Seventy-four (94.9%) biopsies were designated as polyps or nodules and 46.6% were located in the mid-esophagus. Other abnormal findings included gastroesophageal reflux disease (48.6%), hiatal hernia (38.9%), and esophagitis (36.1%). For the PUMCH cohort, 63 754 upper endoscopies were performed and 73 biopsies from 71 patients were identified as ESP (F:M = 48:23, 71.8% > 45 years). Sixty-four (87.7%) biopsies were designated as polyps or nodules and 57.5% were located in the mid-esophagus. Other abnormal findings included esophagitis (19.7%), and hiatal hernia (8.5%). No features of conventional cytologic dysplasia or viral cytopathic change were found. None of the cases was associated with squamous cell carcinoma, and none showed positive HPV RNA ISH results. Conclusions: No association was found between ESP and active HPV infection in our 2 cohorts. Other etiopathogenetic mechanisms, such as aging, might contribute to the development of these innocent lesions.
摘要：
简介：食管鳞状乳头状瘤（ESP）的病因尚不清楚。先前的研究显示与人乳头瘤病毒（HPV）的可变关联与数据冲突。这项研究的目的是使用RNA原位杂交（ISH）进一步调查我们的ESP系列中HPV的可能关联，并比较来自美国和中国的研究组。方法：收集来自加州大学洛杉矶分校（UCLA）（2016/1-2019/3）和北京协和医院（PUMCH）（2014/9-2019/3）病理数据库的ESP患者的人口学和临床资料。重新检查苏木精和伊红载玻片。通过高危型和低危型HPVRNAISH检查确诊病例。结果：对于UCLA队列，进行了13429例上消化道内窥镜检查，72例患者的78例活检被确定为ESP（F：M=45：27，66.7％>45岁）。74例（94.9％）活检被指定为息肉或结节，46.6％位于食管中部。其他异常发现包括胃食管反流病（48.6%），食管裂孔疝(38.9%),和食管炎(36.1%)。对于PUMCH队列，进行了63754例上消化道内窥镜检查，71例患者的73例活检被确定为ESP（F：M=48：23，71.8％>45岁）。64例（87.7％）活检被指定为息肉或结节，57.5％位于食管中部。其他异常发现包括食管炎（19.7%），和食管裂孔疝（8.5%）。未发现常规细胞学发育异常或病毒性细胞病变的特征。这些病例都没有与鳞状细胞癌相关，无HPVRNAISH阳性结果。结论：在我们的两个队列中，ESP和活动性HPV感染之间没有发现关联。其他病因机制，如衰老，可能有助于这些无辜病变的发展。
