Abstract：
Studies on human papillomavirus (HPV) infection in oropharyngeal squamous papilloma (OPSP) are lacking, although HPV infection has been recognized as the primary cause of oropharyngeal cancer for several decades. This study aimed to evaluate the prevalence and characteristics of HPV infections in patients with OPSP. We retrospectively enrolled patients with histologically confirmed OPSP in whom the presence of HPV infections and p16 expression were evaluated. The results of HPV infection in OPSP were analyzed according to the clinicodemographic profiles. Of the 83 patients included in this study, HPV test results were positive in 12 patients, with an overall prevalence of 14.5%. HPV genotypes involved low-risk and high-risk HPV types in three (3.6%) and nine (10.8%) patients, respectively. The most prevalent genotype was HPV16, accounting for 58.3% of all HPV infections. None of the OPSPs showed p16 IHC positivity. There were trends toward a higher prevalence of high-risk HPV infection in patients with OPSP aged ≤45 years, never-smokers, and those with multifocal diseases. These findings could enhance our understanding of HPV infection in OPSP and be used as valuable epidemiological data for the management of HPV-associated OPSP and regarding the possible efficacy of HPV vaccinations in OPSP.
摘要：
缺乏关于口咽鳞状乳头状瘤（OPSP）中人乳头瘤病毒（HPV）感染的研究，尽管几十年来HPV感染一直被认为是口咽癌的主要原因。本研究旨在评估OPSP患者HPV感染的患病率和特征。我们回顾性招募了组织学证实的OPSP患者，其中评估了HPV感染和p16表达的存在。根据临床人口统计学分析OPSP中HPV感染的结果。在这项研究中纳入的83名患者中，12例患者HPV检测结果为阳性,总体患病率为14.5%。HPV基因型涉及三名（3.6％）和九名（10.8％）患者的低风险和高风险HPV类型。分别。最流行的基因型是HPV16，占所有HPV感染的58.3％。OPSP均未显示p16IHC阳性。在年龄≤45岁的OPSP患者中，高危型HPV感染率有较高的趋势。从不吸烟者,和那些患有多灶性疾病的人。这些发现可以增强我们对OPSP中HPV感染的理解，并可用作有价值的流行病学数据，用于HPV相关OPSP的管理以及HPV疫苗在OPSP中的可能功效。
