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Abstract：
Human papillomavirus (HPV) infection has emerged as an etiologic factor of squamous papilloma (SP). The oropharynx and larynx are common sites of SP, but studies on the prevalence of HPV infection in these sites are lacking. This study aimed to evaluate and compare the prevalence and characteristics of HPV infection in oropharyngeal SP (OPSP) and laryngeal SP (LSP). HPV detection and genotyping data of patients with pathologically confirmed OPSP and LSP were retrospectively analyzed. A total of 119 patients were enrolled, consisting of 93 patients with OPSP and 26 patients with LSP. Of those patients, 13 patients with OPSP and 14 patients with LSP were positive for HPV infection, accounting for a prevalence of 14.0% and 53.8%, respectively (p < 0.001). The most prevalent genotype was HPV16 in OPSP and HPV6 in LSP. Over two-thirds (69.2%) of HPV(+)-OPSP infections were high-risk types compared with 14.3% of HPV(+)-LSP infections (p = 0.004). The prevalence of HPV infection in patients with OPSP and LSP demonstrated no differences in terms of age, sex, and smoking status. These results could provide a better understanding of HPV infection in OPSP and LSP and serve as a background for the epidemiology of HPV-related tumorigenesis of the oropharynx and larynx.
摘要：
人乳头瘤病毒（HPV）感染已成为鳞状乳头状瘤（SP）的病因。口咽和喉是SP的常见部位，但缺乏对这些部位HPV感染患病率的研究.本研究旨在评估和比较口咽SP（OPSP）和喉SP（LSP）中HPV感染的患病率和特征。回顾性分析经病理证实的OPSP和LSP患者的HPV检测和基因分型资料。共纳入119例患者，由93例OPSP患者和26例LSP患者组成。这些病人中,13例OPSP患者和14例LSP患者HPV感染阳性，占患病率的14.0%和53.8%，分别(p<0.001)。最普遍的基因型是OPSP中的HPV16和LSP中的HPV6。超过三分之二（69.2％）的HPV（+）-OPSP感染是高危类型，而HPV（+）-LSP感染为14.3％（p=0.004）。OPSP和LSP患者HPV感染的患病率在年龄方面没有差异。性别,和吸烟状况。这些结果可以更好地了解OPSP和LSP中的HPV感染，并作为口咽和喉HPV相关肿瘤发生的流行病学背景。
