背景:治疗失语症患者是一个主要的治疗挑战。本研究评估了富血小板血浆(PRP)在治疗鼻窦息肉病患者的嗅觉缺失中的疗效。方法:在本临床试验中,纳入48例完成药物治疗并在鼻窦手术后3个月观察的伊朗气味识别测试(I-SIT)评分<6的鼻窦息肉病患者,并随机分为2组。内窥镜鼻窦手术后,干预组和对照组在嗅区鼻内注射1mLPRP和生理盐水,分别。在基线和研究结束时通过独立样品t检验使用I-SIT评估气味功能。结果:根据本研究的结果,随访期间两组的I-SIT均有所改善,干预组在口服类固醇后达到2.63±2.63至5.85±2.46,在手术后达到18.93±1.14,在接受标准药物治疗后从基线为2.10±2.83至5.62±2.99,在手术后对照组为18.43±1.36。尽管在任何时间间隔内,两组的这种改善都是显着的(均为p<0.001),在I-SIT评分的变化方面,两组之间没有显着差异(p=0.802)。结论:根据目前的研究,PRP注射对鼻窦息肉患者嗅觉功能的恢复无短期影响。
Background: Treatment of patients with anosmia is a major therapeutic challenge. The present
study evaluated the efficacy of platelet-rich plasma (PRP) in the treatment of anosmia in patients with sinonasal polyposis. Methods:In the present clinical
trial, atotal of 48 patients with sinonasal polyposis with theIran Smell Identification Test (I-SIT) score of <6 who completed the medical treatment and were observed 3 months after the sinus surgery were included and randomly divided in to 2groups. After endoscopic sinus surgery, the intranasal injection of 1 mL PRP and normal saline was performed in the olfactory region in the intervention and control groups, respectively. Odor function was assessed using the I-SIT at the baseline and at the end of the studyby an independent samples ttest. Results: Based on the findings of the present
study, the I-SIT improved in both groups during the follow-up, as it reached from 2.63 ± 2.63 to 5.85 ± 2.46 after oral steroid administration and 18.93 ± 1.14 after surgery in the intervention group and from the baseline of 2.10 ± 2.83 to 5.62 ± 2.99 after receiving standard medical treatment and 18.43 ± 1.36in the control groupafter surgery. Although this improvement was significant in both groups in either time interval (all with p<0.001), there was no significant difference between the 2groups in terms of changes in the I-SIT score (p=0.802). Conclusion: According to the current
study, PRP injection showed no short-term effect on the recovery of olfactory function in patients with sinonasal polyposis.