■高级别盆腔浆液性癌是全球和印度女性的常见死亡原因。最近的证据清楚地表明其发病机理涉及输卵管菌毛末端粘膜的变化。
■1)研究子宫和卵巢非肿瘤性病变的输卵管手术切除标本的组织病理学特征,是否存在任何前体病变[分泌细胞生长(SCOUT),浆液性输卵管上皮内病变(STIL),p53信号,和浆液性输卵管上皮内癌(STIC)]。2)用免疫组织化学证实发现。3)将前体病变的患病率与子宫和卵巢的临床参数和良性病变相关联。
■100个远端输卵管标本的组织病理学变化的评估是使用纤维末端的切片和广泛检查(SEE-FIM)方案进行的。H和E染色,然后进行Bcl-2,p53和Ki-67的免疫组织化学。通过非配对t检验评估前体面积的平均值差异的统计显著性。
■在H和E上采集的100个样本中,49%的病例怀疑有前驱病变.SCOUT,可疑的STIC,可疑的STIC与SCOUT区域,对于STIC来说,有8%的SCOUT区域是显而易见的,4%,33%,4%的病例,分别。然而,在IHC上,在45%的病例中确认了SCOUTS,2%的p53签名,STIL在9%,和STIC在4%的病例中。
■应常规进行纤毛末端的切片和广泛检查(SEE-FIM),因为它提供了检测早期恶性变化的机会。它可能有助于发展早期发现的策略,管理,降低死亡率。
UNASSIGNED: High-grade pelvic serous carcinoma is a common cause of death in women worldwide and India. Recent evidence has clearly implicated the changes in the mucosa of the fimbrial end of the fallopian tube in its pathogenesis.
UNASSIGNED: 1) To study histopathology features of surgically resected specimens of fallopian tubes received with non-neoplastic lesions of the uterus and ovary for the presence of any precursor lesions [secretory cell outgrowth (SCOUT), serous tubal intraepithelial lesion (STIL), p53 signatures, and serous tubal intraepithelial carcinoma (STIC)]. 2) To confirm the findings with immunohistochemistry. 3) To correlate the prevalence of precursor lesions with clinical parameters and benign lesions of the uterus and ovaries.
UNASSIGNED: Assessment of histopathological changes in 100 specimens of distal fallopian tubes was done using the sectioning and extensive examination of the fimbrial end (SEE-FIM) protocol. H and E stain followed by immunohistochemistry for Bcl-2, p53, and Ki-67. The statistical significance of the difference in the mean values of precursor areas was evaluated by an unpaired t-test.
UNASSIGNED: Among 100 specimens taken on H and E, precursor lesions were suspected in 49% of the cases. SCOUT, suspicious for STIC, suspicious for STIC with areas of SCOUT, and unequivocal for STIC with areas of SCOUT were seen in 8%, 4%, 33%, and 4% of the cases, respectively. However, on IHC, SCOUTS were confirmed in 45% of the cases, p53 signature in 2%, STIL in 9%, and STIC in 4% of the cases.
UNASSIGNED: Sectioning and extensive examination of the fimbrial end (SEE-FIM) should be routinely done as it provides the opportunity to detect the early malignant changes. It may help in evolving the strategies for early detection, management, and reducing mortality.