UNASSIGNED:使用常规磁共振成像(MRI)有时难以有效区分非肿瘤性和肿瘤性颅内增强病变。这项研究旨在评估三维伪连续动脉自旋标记(3D-pCASL)的诊断性能,以区分非肿瘤性和肿瘤性增强病变。
UNASSIGNED:这项前瞻性研究包括35例高级别胶质瘤(HGG)患者,12例脑转移患者,15名非肿瘤患者接受了常规治疗,3.0TMR增强和3D-pCASL成像;所有病变均显着增强。使用Studentt检验比较了肿瘤和非肿瘤之间的定量参数,包括脑血流量(CBF)和相对脑血流量(rCBF)。此外,测量受试者工作特征(ROC)曲线下面积(AUC)以评估各参数的鉴别诊断性能.
UNASSIGNED:与肿瘤组相比,非肿瘤组表现出明显更低的病变和病灶周围水肿的rCBF值。对于ROC分析,病灶的相对脑血流量(rCBF-L)和病灶周围水肿的相对脑血流量(rCBF-PE)对于区分非肿瘤性和肿瘤性病变具有良好的诊断性能,AUC分别为0.994和0.846。
未经证实:3D-pCASL可能有助于区分非肿瘤性和肿瘤性病变。
UNASSIGNED: It is sometimes difficult to effectively distinguish non-neoplastic from neoplastic intracranial enhancement lesions using conventional magnetic resonance imaging (MRI). This study aimed to evaluate the diagnostic performance of three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL) to differentiate non-neoplastic from neoplastic enhancement lesions intracranially.
UNASSIGNED: This prospective study included thirty-five patients with high-grade gliomas (HGG), twelve patients with brain metastasis, and fifteen non-neoplastic patients who underwent conventional, contrast enhancement and 3D-pCASL imaging at 3.0-T MR; all lesions were significantly enhanced. Quantitative parameters including cerebral blood flow (CBF) and relative cerebral blood flow (rCBF) were compared between neoplastic and non-neoplastic using Student\'s t-test. In addition, the area under the receiver operating characteristic (ROC) curve (AUC) was measured to assess the differentiation diagnostic performance of each parameter.
UNASSIGNED: The non-neoplastic group demonstrated significantly lower rCBF values of lesions and perilesional edema compared with the neoplastic group. For the ROC analysis, both relative cerebral blood flow of lesion (rCBF-L) and relative cerebral blood flow of perilesional edema (rCBF-PE) had good diagnostic performance for discriminating non-neoplastic from neoplastic lesions, with an AUC of 0.994 and 0.846, respectively.
UNASSIGNED: 3D-pCASL may contribute to differentiation of non-neoplastic from neoplastic lesions.