Abstract：
OBJECTIVE: Distinguishing non-neoplastic tumour-mimicking pathologies from bone and soft tissue tumours is one of the fundamental aims of a tertiary centre sarcoma multidisciplinary team (MDT) service. In this study, we aim to analyse the incidence of non-neoplastic lesions referred to a tertiary referral service as suspected sarcoma, and to analyse the spectrum of conditions comprising these tumour-mimicking pathologies.
METHODS: We conducted a retrospective observational study compiling the biopsy-proven non-neoplastic outcomes of suspected sarcoma cases referred to our MDT in the last year. We identified all referrals made to our service between 1st January 2020 and 31st December 2020 and compiled their histological diagnoses.
RESULTS: A total of 976 new cases were referred to our MDT as suspected sarcoma in one year. Of these referrals, 8.6% (84/976) received a biopsy-proven outcome of non-neoplastic pathology. These non-neoplastic outcomes were categorised into the following types of pathology: 32.1% vascular, 31.0% inflammatory, 14.3% traumatic, 6.0% degenerative, 6.0% idiopathic, 4.8% infective, 3.6% metabolic, 1.2% autoimmune, and 1.2% genetic.
CONCLUSIONS: A significant proportion of pathologies referred to a tertiary centre sarcoma MDT are non-neoplastic in nature. These lesions are made up of a range of pathologies, with vascular and inflammatory conditions being the most common. Our study, the first of its kind, offers clinicians an insight into tumour-mimicking pathologies encountered by a tertiary centre.
METHODS: We conducted a retrospective observational study compiling the biopsy-proven non-neoplastic outcomes of suspected sarcoma cases referred to our MDT in the last year. We identified all referrals made to our service between 1st January 2020 and 31st December 2020 and compiled their histological diagnoses.
RESULTS: A total of 976 new cases were referred to our MDT as suspected sarcoma in one year. Of these referrals, 8.6% (84/976) received a biopsy-proven outcome of non-neoplastic pathology. These non-neoplastic outcomes were categorised into the following types of pathology: 32.1% vascular, 31.0% inflammatory, 14.3% traumatic, 6.0% degenerative, 6.0% idiopathic, 4.8% infective, 3.6% metabolic, 1.2% autoimmune, and 1.2% genetic.
CONCLUSIONS: A significant proportion of pathologies referred to a tertiary centre sarcoma MDT are non-neoplastic in nature. These lesions are made up of a range of pathologies, with vascular and inflammatory conditions being the most common. Our study, the first of its kind, offers clinicians an insight into tumour-mimicking pathologies encountered by a tertiary centre.
摘要：
目的：从骨骼和软组织肿瘤中区分非肿瘤性肿瘤模拟病理是三级中心肉瘤多学科团队（MDT）服务的基本目标之一。在这项研究中,我们的目的是分析非肿瘤性病变的发生率，这些非肿瘤性病变被称为三级转诊服务，并分析包含这些肿瘤模拟病理的条件谱。
方法：我们进行了一项回顾性观察研究，收集了去年我们的MDT转诊的疑似肉瘤病例的活检证实的非肿瘤性结局。我们确定了2020年1月1日至2020年12月31日期间向我们提供服务的所有转诊，并编制了其组织学诊断。
结果：在一年内，共有976例新病例作为疑似肉瘤转诊到我们的MDT。在这些推荐中，8.6%(84/976)接受了活检证实的非肿瘤性病理学结果。这些非肿瘤性结局分为以下病理类型：32.1%血管，31.0%炎症，14.3%创伤,6.0%退行性，6.0％特发性，4.8%感染,3.6%代谢，1.2%自身免疫，和1.2％的遗传。
结论：涉及三级中心肉瘤MDT的大部分病理本质上是非肿瘤性的。这些病变由一系列病理组成，血管和炎症是最常见的。我们的研究,这是同类中的第一个，为临床医生提供了对三级中心遇到的肿瘤模拟病理的见解。
方法：我们进行了一项回顾性观察研究，收集了去年我们的MDT转诊的疑似肉瘤病例的活检证实的非肿瘤性结局。我们确定了2020年1月1日至2020年12月31日期间向我们提供服务的所有转诊，并编制了其组织学诊断。
结果：在一年内，共有976例新病例作为疑似肉瘤转诊到我们的MDT。在这些推荐中，8.6%(84/976)接受了活检证实的非肿瘤性病理学结果。这些非肿瘤性结局分为以下病理类型：32.1%血管，31.0%炎症，14.3%创伤,6.0%退行性，6.0％特发性，4.8%感染,3.6%代谢，1.2%自身免疫，和1.2％的遗传。
结论：涉及三级中心肉瘤MDT的大部分病理本质上是非肿瘤性的。这些病变由一系列病理组成，血管和炎症是最常见的。我们的研究,这是同类中的第一个，为临床医生提供了对三级中心遇到的肿瘤模拟病理的见解。
