急性运动对维生素D代谢物循环浓度的影响尚不清楚。为了解决这个知识差距,我们研究了基于跑步机的运动与休息对健康男性和女性循环浓度25(OH)D3,25(OH)D2,3-epi-25(OH)D3,24,25(OH)2D3,1,25(OH)2D3和维生素D2和D3的影响.33名健康成年人(14名女性,41(15)年,身体质量指数26.2(3.7)kg/m2,最大{{\\dot{V}}_{{{{\\mathrm{O}}}_{\\mathrm{2}}}{\\mathrm{\\mathrm}}}}$36.2(9.2)ml/kg/min;平均(SD)完成两次实验室检查,包括{\morthral-都处于过夜禁食状态,作为随机交叉设计的一部分。在基线时抽取静脉血样,立即(0h),运动或休息时间后1小时和24小时。总循环25(OH)D存在显著的时间×试验交互作用(P=0.0148),25(OH)D3(P=0.0127)和1,25(OH)2D3(P=0.0226)。运动后立即,25(OH)D,25(OH)D3和1,25(OH)2D3浓度与对照静息条件相比显著升高,1,25(OH)2D3在1小时后仍显着升高。循环白蛋白,维生素D结合蛋白,钙和甲状旁腺激素在运动后立即升高.因此,与静息条件相比,急性中等强度运动会短暂增加循环25(OH)D和1,25(OH)2D3的浓度。关键点:观察性研究表明,急性运动可能会改变维生素D代谢产物的循环浓度,但尚未使用随机交叉研究和稳健的分析程序进行调查。在这项研究中,我们使用随机交叉设计来检查一次基于跑步机的锻炼的效果(与休息)对健康人体内多种维生素D代谢物的循环浓度。我们表明,与静息条件相比,急性中等强度运动会短暂增加循环25(OH)D和1,25(OH)2D3的浓度。这些发现表明,定期运动可能导致短暂但有规律的维生素D生物学作用增强的窗口。
The effect of acute exercise on circulating concentrations of vitamin D metabolites is unclear. To address this knowledge gap, we examined the effect of a bout of treadmill-based exercise versus rest on circulating concentrations of 25(OH)D3, 25(OH)D2, 3-epi-25(OH)D3, 24,25(OH)2D3, 1,25(OH)2D3, and vitamin D2 and D3 in healthy men and women. Thirty-three healthy adults (14 females, 41 (15) years, body mass index 26.2 (3.7) kg/m2, V ̇ O 2 max ${{\\dot{V}}_{{{{\\mathrm{O}}}_{\\mathrm{2}}}{\\mathrm{max}}}}$ 36.2 (9.2) ml/kg/min; mean (SD)) completed two laboratory visits involving 60 min of moderate-intensity treadmill exercise (60% V ̇ O 2 max ${{\\dot{V}}_{{{{\\mathrm{O}}}_{\\mathrm{2}}}{\\mathrm{max}}}}$ ) versus 60 min of seated rest, both in an overnight fasted-state, as part of a randomised crossover design. Venous blood samples were drawn at baseline, immediately (0 h), 1 h and 24 h after the exercise or rest-period. There was a significant time ×
trial interaction effect for total circulating 25(OH)D (P = 0.0148), 25(OH)D3 (P = 0.0127) and 1,25(OH)2D3 (P = 0.0226). Immediately post-exercise, 25(OH)D, 25(OH)D3 and 1,25(OH)2D3 concentrations were significantly elevated compared to the control resting condition, and 1,25(OH) 2D3 remained significantly elevated 1 h later. Circulating albumin, vitamin D binding protein, calcium and parathyroid hormone were elevated immediately post-exercise. Thus, an acute bout of moderate intensity exercise transiently increases concentrations of circulating 25(OH)D and 1,25(OH)2D3 compared to resting conditions. KEY POINTS: Observational studies suggest that acute exercise might change circulating concentrations of vitamin D metabolites, but this has not been investigated using randomised crossover studies and using robust analytical procedures. In this
study, we used a randomised crossover design to examine the effect of a bout of treadmill-based exercise (vs. rest) on circulating concentrations of a wide range of vitamin D metabolites in healthy humans. We show that an acute bout of moderate intensity exercise transiently increases concentrations of circulating 25(OH)D and 1,25(OH)2D3 compared to resting conditions. These findings indicate that regular exercise could lead to transient but regular windows of enhanced vitamin D biological action.