背景:制药行业开发了脱氧胆酸(DCA),用于减少下脂肪的美学用途。它代表了食品和药物管理局(FDA)批准的第一个脂肪分解物质,用于该领域的脂肪减少。
目的:本研究更新了DCA的特性和用途,以及不良事件和可能的并发症。
方法:在MEDLINE/PubMed中搜索,科克伦,和Bireme/LILACS数据库使用以下术语进行:\"脱氧胆酸\"或\"ATX-101\"和\"注射\"NOT\"两性霉素\"NOT\"胆汁\"NOT\"胆汁。“在动物中进行的实验研究,临床试验,文献综述,病例报告,以及给编辑的信,其中包括DCA的作用机制,剂量,使用方式,不利影响,并选择并发症。
结果:最常见的不良事件是水肿,局部疼痛,瘀伤,麻木,通常自发地消退。然而,并发症,包括,皮肤坏死,神经损伤,脱发,血管事件,可能发生,要求复杂的管理没有具体的协议。
结论:虽然DCA有利于脂肪组织的溶解,临床医生应了解使用该物质的不良反应和风险.局部解剖学的知识,属性,不良反应是DCA治疗的基础。
BACKGROUND: Deoxycholic acid (DCA) was developed by the pharmaceutical industry for aesthetical use in submental fat reduction. It represents the first lipolytic substance approved by the Food and Drug Administration (FDA) for fat reduction in that area.
OBJECTIVE: This study presents an update of properties and the use of DCA, as well as adverse events and possible complications.
METHODS: A search in MEDLINE/PubMed, Cochrane, and Bireme/LILACS databases was performed using the terms: \"deoxycholic acid\" OR \"ATX-101\" AND \"injection\" NOT \"amphotericin\" NOT \"biliary\" NOT \"bile.\" Experimental studies developed in animals, clinical trials, literature reviews, case reports, and letters to the editor that included the DCA mechanism of action, dose, manner of use, adverse effects, and complications were selected.
RESULTS: The most frequent adverse events are edema, local pain, bruise, and numbness, which usually spontaneously regress. However, complications, including, skin necrosis, nerve injury, alopecia, and vascular events, can occur, demanding complex management without specific protocols.
CONCLUSIONS: Although DCA is beneficial for lysis of adipose tissue, clinicians should be aware about the adverse effects and risks involved with the use of this substance. The knowledge of local anatomy, properties, and adverse effects are fundamental to treatment with DCA.