■对脑MRI的观察性研究进行系统评价和荟萃分析,本文评估了长期暴露于高海拔地区对健康人大脑结构的影响。
■与高海拔有关的观察性研究,根据从PubMed检索到的数据,系统地搜索大脑和MRI,Embase和Cochrane图书馆。收集文献的时间表是从建立数据库到2023年。NoteExpress3.2用于管理文献。两名研究者根据纳入标准进行文献筛选和数据提取,排除标准,和文学质量。文献质量采用NOS量表进行评价。最后,使用ReviewerManager5.3对纳入研究进行荟萃分析。
■最初,检索到3626篇文章。筛选后,16篇文章(n=756名参与者)被纳入系统评价,对6篇文章(n=350名参与者)进行荟萃分析。收录文章的总体质量处于中等水平,平均NOS评分为5.62。Meta分析结果显示,HA组与LA组间差异无统计学意义,总GM体积(MD:-0.60,95%CI:-16.78至15.58,P=0.94),WM体积(MD:3.05,95%CI:-15.72至21.81,P=0.75)和CSF体积(MD:5.00,95%CI:-11.10至21.09,P=0.54)。HA和LA在额颞叶FA值的差异无统计学意义:右额叶(MD:-0.02,95%CI:-0.07至0.03,P=0.38),左额叶(MD:0.01,95%CI:-0.02至0.04,P=0.65),右颞叶(MD:-0.00,95%CI:-0.03至0.02,P=0.78)和左颞叶(MD:-0.01,95%CI:-0.04至0.02,P=0.62)。然而,转基因体积有显著差异,HA组和LA组之间局部脑区的GM密度和FA值。
■与洛杉矶地区相比,总GM没有显著差异,长期生活在高海拔地区的健康人的WM和CSF体积,而大脑局部区域的GM体积和FA值存在显着差异。长期暴露于高海拔地区会导致局部大脑区域的适应性结构变化。由于研究之间存在异质性,需要进一步的研究来揭示高海拔对健康人大脑的影响。
■https://www.crd.约克。AC.英国/普华永道/,标识符:CRD42023403491。
UNASSIGNED: To conduct a systematic
review and meta-analysis of observational studies of brain MRI, this paper assesses the effects of long-term exposure to high-altitude on brain structures in healthy people.
UNASSIGNED: Observational studies related to high-altitude, brain and MRI were systematically searched based on data retrieved from PubMed, Embase and Cochrane Library. The timescale for collecting literature was from the establishment of the databases to 2023. NoteExpress 3.2 was used to manage the literature. Two investigators performed literature screening and data extraction based on inclusion criteria, exclusion criteria, and literature quality. The quality of the literature was assessed using the NOS Scale. Finally, meta-analysis of included studies was performed using Reviewer Manager 5.3.
UNASSIGNED: Initially, 3,626 articles were retrieved. After screening, 16 articles (n = 756 participants) were included in the systematic
review, and meta-analysis was performed on 6 articles (n = 350 participants). The overall quality of the included articles was at medium level, with a mean NOS score of 5.62. The results of meta-analysis showed that the differences between the HA group and LA group were not statistically significant, in total GM volume (MD: -0.60, 95% CI: -16.78 to 15.58, P = 0.94), WM volume (MD: 3.05, 95% CI: -15.72 to 21.81, P = 0.75) and CSF volume (MD: 5.00, 95% CI: -11.10 to 21.09, P = 0.54).The differences between HA and LA in FA values of frontotemporal lobes were not statistically significant: right frontal lobe (MD: -0.02, 95% CI: -0.07 to 0.03, P = 0.38), left frontal lobe (MD: 0.01, 95% CI: -0.02 to 0.04, P = 0.65), right temporal lobe (MD: -0.00, 95% CI: -0.03 to 0.02, P = 0.78) and left temporal lobe (MD: -0.01, 95% CI: -0.04 to 0.02, P = 0.62). However, there were significant differences in GM volume, GM density and FA values in local brain regions between HA group and LA group.
UNASSIGNED: Compared with LA area, there were no significant differences in total GM, WM and CSF volumes in healthy people living at high-altitude area for long-term, while there were significant differences in GM volume and FA values in local brain regions. Long-term exposure to high-altitude area caused the adaptive structural changes in local brain regions. Since heterogeneity existed between the studies, further studies are needed to uncover the effects of high-altitude on brain of healthy people.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier: CRD42023403491.