Abstract：
Kharel, Sanjeev, Suraj Shrestha, Samriddha Raj Pant, Suman Acharya, Amit Sharma, Santosh Baniya, and Sanjeeb S. Bhandari. High-altitude exposure and cerebral venous thrombosis: an updated systematic review. High Alt Med Biol. 24:167-174, 2023. Background: High altitude (HA) may increase the risk of cerebral venous thrombosis (CVT). Differentiating it from other HA illnesses is crucial for prompt treatment and better outcomes. We aimed to summarize the clinical data, etiology, and risk factors of this poorly understood entity at an HA. Materials and Methods: A systematic literature search of various databases, including PubMed, Embase, and Google Scholar, was done using relevant keywords; cerebral venous thrombosis; HA, up to May 1, 2022. Results: A total of nine studies, including 75 cases of CVT at HA (3,000-8,848 m), with 66 males and 9 females, were included in this review. Headache and seizure were the most common clinical presentations. Smoking, drinking habits, and the use of oral contraceptive pills (OCP) were the most common risk factors for the development of CVT. Similarly, various underlying hypercoagulable states were also present among cases of CVT associated with HA exposure. Conclusion: Our review concludes that HA exposure can predispose individuals with risk factors such as preexisting hypercoagulable states, smoking, drinking habits, and use of OCP to an increased risk of CVT.
摘要：
卡雷尔,Sanjeev,SurajShrestha,SamriddhaRaj裤子,SumanAcharya,AmitSharma,SantoshBaniya,和SanjeebS.Bhandari.高原暴露与脑静脉血栓形成：一项最新的系统评价。高AltMedBiol。24:000-000，2023年。背景：高海拔（HA）可能会增加脑静脉血栓形成（CVT）的风险。将其与其他HA疾病区分开来对于及时治疗和更好的结果至关重要。我们旨在总结临床数据，病因学,以及在医管局对这个知之甚少的实体的风险因素。材料与方法：对各种数据库进行系统的文献检索，包括PubMed,Embase,和谷歌学者，使用相关关键词完成；脑静脉血栓形成；HA，到2022年5月1日结果:共9项研究,包括房委会75例CVT(3,000-8,848米)，有66名男性和9名女性，包括在这次审查中。头痛和癫痫发作是最常见的临床表现。吸烟,饮酒习惯,口服避孕药（OCP）的使用是CVT发展的最常见危险因素。同样，在与HA暴露相关的CVT病例中也存在各种潜在的高凝状态.结论：我们的综述得出的结论是，HA暴露可能会使个体具有危险因素，例如预先存在的高凝状态，吸烟,饮酒习惯,和使用OCP增加CVT的风险。
