背景:血清尿酸(SUA)是心脑血管疾病的主要病因。SUA是否以及在多大程度上导致血管周围间隙(EPVS)增大的风险尚不清楚。这项研究是为了调查不同脑区SUA和EPVS之间的关联。
方法:数据来自本横断面研究中基于开联研究(META-KLS)的多模态医学成像研究。参与者根据SUA水平分为五组,和基底神经节(BG)中的EPVS,系统评估半卵中心(CSO)和中脑(MB),并分为低组和高组。使用多变量逻辑回归分析估计高EPVS结果的比值比(OR)和95%置信区间(95%CIs)。限制性三次样条(RCS)用于进一步研究剂量反应关系。
结果:共有来自11个中心的1014名25-83岁的参与者参加了这项研究。在多变量调整模型中,SUA,作为一个独立的风险因素,与高度MB-EPVS呈正相关(OR,1.002;95%CI,1.000至1.004;p=0.023)在一般人群中。此外,RCS进一步证明了SUA和MB-EPVS之间的线性关系(p=0.072)。SUA与BG-EPVS或CSO-EPVS之间未发现关联。
结论:SUA是MB-EPVS的独立危险因素。高SUA水平更能预测高水平MB-EPVS发生的风险。支持SUA和MB-EPVS之间的线性关联,并进一步表明SUA可能在脑小血管疾病中发挥重要作用。
背景:开联研究和META-KLS在线注册(ChiCTR2000029767在chictr.org上。cn和NCT05453877onClinicaltrials.gov,分别)。
BACKGROUND: Serum uric acid (SUA) is a major cause of cardiovascular and cerebrovascular diseases. Whether and to what extent the excess risk of enlarged perivascular spaces (EPVS) conferred by SUA is unknown. The
study was conducted to investigate the association between SUA and EPVS in different brain regions.
METHODS: Data are from Multi-modality medical imaging
study based on Kailuan
study (META-KLS) in this cross-sectional
study. Participants were divided into five groups based on SUA levels, and EPVS in basal ganglia (BG), centrum semiovale (CSO) and midbrain (MB) was systematically assessed and divided into Low and High group. Odds ratio (OR) and 95% confidence intervals (95% CIs) for high EPVS outcomes were estimated using multivariable logistic regression analysis. Restricted cubic spline (RCS) was used to further investigate dose-response relationship.
RESULTS: A total of 1014 participants aged 25-83 years from 11 centers were enrolled in the
study. In the multivariable-adjusted model, SUA, as an independent risk factor, correlated positively with high degree of MB-EPVS (OR, 1.002; 95% CI, 1.000 to 1.004; p = 0.023) in general population. In addition, RCS further demonstrated the linear association between SUA and MB-EPVS (p = 0.072). No association was found between SUA and BG-EPVS or CSO-EPVS.
CONCLUSIONS: SUA was an independent risk factor of MB-EPVS. High SUA levels were more predictive of increased risk occurrence of high degree of MB-EPVS, supporting a linear association between SUA and MB-EPVS and further indicating that SUA may play an important role in cerebral small vessel disease.
BACKGROUND: The KaiLuan
Study and META-KLS were registered online (ChiCTR2000029767 on chictr.org.cn and NCT05453877 on Clinicaltrials.gov, respectively).