PDF(Pubmed)
Abstract：
UNASSIGNED: Mild cognitive impairment (MCI) is a critical transitional phase from healthy cognitive aging to dementia, offering a unique opportunity for early intervention. However, few studies focus on the correlation of brain structure and functional activity in patients with MCI due to Alzheimer\'s disease (AD). Elucidating the complex interactions between structural-functional (SC-FC) brain connectivity and glymphatic system function is crucial for understanding this condition.
UNASSIGNED: The aims of this study were to explore the relationship among SC-FC coupling values, glymphatic system function and cognitive function. 23 MCI patients and 18 healthy controls (HC) underwent diffusion tensor imaging (DTI) and resting-state functional MRI (fMRI). DTI analysis along the perivascular space (DTI-ALPS) index and SC-FC coupling values were calculated using DTI and fMRI. Correlation analysis was conducted to assess the relationship between Mini-Mental State Examination (MMSE) scores, DTI-ALPS index, and coupling values. Receiver operating characteristic (ROC) curves was conducted on the SC-FC coupling between the whole brain and subnetworks. The correlation of coupling values with MMSE scores was also analyzed.
UNASSIGNED: MCI patients (67.74 ± 6.99 years of age) exhibited significantly lower coupling in the whole-brain network and subnetworks, such as the somatomotor network (SMN) and ventral attention network (VAN), than HCs (63.44 ± 6.92 years of age). Whole-brain network coupling was positively correlated with dorsal attention network (DAN), SMN, and visual network (VN) coupling. MMSE scores were significantly positively correlated with whole-brain coupling and SMN coupling. In MCI, whole-brain network demonstrated the highest performance, followed by the SMN and VAN, with the VN, DAN, limbic network (LN), frontoparietal network (FPN), and default mode network (DMN). Compared to HCs, lower DTI-ALPS index was observed in individuals with MCI. Additionally, the left DTI-ALPS index showed a significant positive correlation with MMSE scores and coupling values in the whole-brain network and SMN.
UNASSIGNED: These findings reveal the critical role of SC-FC coupling values and the ALPS index in cognitive function of MCI. The positive correlations observed in the left DTI-ALPS and whole-brain and SMN coupling values provide a new insight for investigating the asymmetrical nature of cognitive impairments.
UNASSIGNED: The aims of this study were to explore the relationship among SC-FC coupling values, glymphatic system function and cognitive function. 23 MCI patients and 18 healthy controls (HC) underwent diffusion tensor imaging (DTI) and resting-state functional MRI (fMRI). DTI analysis along the perivascular space (DTI-ALPS) index and SC-FC coupling values were calculated using DTI and fMRI. Correlation analysis was conducted to assess the relationship between Mini-Mental State Examination (MMSE) scores, DTI-ALPS index, and coupling values. Receiver operating characteristic (ROC) curves was conducted on the SC-FC coupling between the whole brain and subnetworks. The correlation of coupling values with MMSE scores was also analyzed.
UNASSIGNED: MCI patients (67.74 ± 6.99 years of age) exhibited significantly lower coupling in the whole-brain network and subnetworks, such as the somatomotor network (SMN) and ventral attention network (VAN), than HCs (63.44 ± 6.92 years of age). Whole-brain network coupling was positively correlated with dorsal attention network (DAN), SMN, and visual network (VN) coupling. MMSE scores were significantly positively correlated with whole-brain coupling and SMN coupling. In MCI, whole-brain network demonstrated the highest performance, followed by the SMN and VAN, with the VN, DAN, limbic network (LN), frontoparietal network (FPN), and default mode network (DMN). Compared to HCs, lower DTI-ALPS index was observed in individuals with MCI. Additionally, the left DTI-ALPS index showed a significant positive correlation with MMSE scores and coupling values in the whole-brain network and SMN.
UNASSIGNED: These findings reveal the critical role of SC-FC coupling values and the ALPS index in cognitive function of MCI. The positive correlations observed in the left DTI-ALPS and whole-brain and SMN coupling values provide a new insight for investigating the asymmetrical nature of cognitive impairments.
摘要：
■轻度认知障碍（MCI）是从健康的认知老化到痴呆的关键过渡阶段，为早期干预提供了独特的机会。然而,很少有研究关注阿尔茨海默病（AD）导致的MCI患者脑结构和功能活动的相关性。阐明结构功能（SC-FC）脑连接与淋巴系统功能之间的复杂相互作用对于理解这种情况至关重要。
■本研究的目的是探索SC-FC耦合值之间的关系，淋巴系统功能和认知功能。23名MCI患者和18名健康对照（HC）接受了扩散张量成像（DTI）和静息状态功能MRI（fMRI）。使用DTI和fMRI计算沿着血管周围间隙的DTI分析(DTI-ALPS)指数和SC-FC偶联值。进行相关分析以评估简易精神状态检查（MMSE）成绩之间的关系，DTI-ALPS指数,和耦合值。在整个大脑和子网络之间的SC-FC耦合上进行了接收器工作特性（ROC）曲线。还分析了偶联值与MMSE评分的相关性。
■MCI患者（67.74±6.99岁）在全脑网络和子网络中表现出明显较低的耦合，如躯体运动网络(SMN)和腹侧注意力网络(VAN)，比HCs（63.44±6.92岁）。全脑网络耦合与背侧注意网络(DAN)呈正相关,SMN,和视觉网络(VN)耦合。MMSE评分与全脑耦合和SMN耦合呈显著正相关。在MCI中，全脑网络表现出最高的性能，其次是SMN和VAN，VN,丹,边缘网络(LN)，额顶叶网络（FPN），和默认模式网络(DMN)。与HC相比，MCI患者的DTI-ALPS指数较低.此外,左侧DTI-ALPS指数与全脑网络和SMN中的MMSE评分和偶联值呈显著正相关.
■这些发现揭示了SC-FC偶联值和ALPS指数在MCI认知功能中的关键作用。在左DTI-ALPS与全脑和SMN耦合值中观察到的正相关为研究认知障碍的不对称性质提供了新的见解。
■本研究的目的是探索SC-FC耦合值之间的关系，淋巴系统功能和认知功能。23名MCI患者和18名健康对照（HC）接受了扩散张量成像（DTI）和静息状态功能MRI（fMRI）。使用DTI和fMRI计算沿着血管周围间隙的DTI分析(DTI-ALPS)指数和SC-FC偶联值。进行相关分析以评估简易精神状态检查（MMSE）成绩之间的关系，DTI-ALPS指数,和耦合值。在整个大脑和子网络之间的SC-FC耦合上进行了接收器工作特性（ROC）曲线。还分析了偶联值与MMSE评分的相关性。
■MCI患者（67.74±6.99岁）在全脑网络和子网络中表现出明显较低的耦合，如躯体运动网络(SMN)和腹侧注意力网络(VAN)，比HCs（63.44±6.92岁）。全脑网络耦合与背侧注意网络(DAN)呈正相关,SMN,和视觉网络(VN)耦合。MMSE评分与全脑耦合和SMN耦合呈显著正相关。在MCI中，全脑网络表现出最高的性能，其次是SMN和VAN，VN,丹,边缘网络(LN)，额顶叶网络（FPN），和默认模式网络(DMN)。与HC相比，MCI患者的DTI-ALPS指数较低.此外,左侧DTI-ALPS指数与全脑网络和SMN中的MMSE评分和偶联值呈显著正相关.
■这些发现揭示了SC-FC偶联值和ALPS指数在MCI认知功能中的关键作用。在左DTI-ALPS与全脑和SMN耦合值中观察到的正相关为研究认知障碍的不对称性质提供了新的见解。
