背景:自从发现淋巴系统以来,人们对探索其与精神疾病的关系的兴趣迫在眉睫。最近,越来越多的证据表明,类淋巴系统参与了精神疾病的病理生理学。然而,仍然缺乏明确的数据。在这种情况下,这项快速综合的PRISMA-ScR(系统评价和Meta分析扩展的首选报告项目)范围审查旨在确定和分析目前关于淋巴淋巴系统和精神疾病之间关系的证据.
方法:我们对文献进行了全面回顾,然后对研究结果进行了叙述讨论。然后构建表格,并根据作者对文章进行排序,Year,title,研究地点,样本量,精神病,研究的目的,主要发现,含义。
结果:20篇论文被确定为合格,其中2篇关于精神分裂症的文章,1自闭症谱系障碍,2关于抑郁症1关于抑郁症和创伤相关疾病,1关于抑郁和焦虑,2关于焦虑和睡眠障碍,8睡眠障碍,2关于酒精使用障碍,1关于可卡因使用障碍。
结论:这篇综述表明,淋巴系统与几种精神疾病之间存在相关性:精神分裂症,抑郁症,焦虑症,睡眠障碍,酒精使用障碍,可卡因使用障碍,创伤相关疾病,和自闭症谱系障碍。淋巴系统受损可能在创伤相关疾病中发挥作用,酒精使用障碍,可卡因使用障碍,睡眠障碍,抑郁症,和自闭症谱系障碍。重要的是要对这一主题进行研究,并采用标准化的标记和无线电诊断工具。
BACKGROUND: Since discovering the glymphatic system, there has been a looming interest in exploring its relationship with psychiatric disorders. Recently, increasing evidence suggests an involvement of the glymphatic system in the pathophysiology of psychiatric disorders. However, clear data are still lacking. In this context, this rapid comprehensive PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) scoping review aims to identify and analyze current evidence about the relation between the glymphatic system and psychiatric disorders.
METHODS: We conducted a comprehensive review of the literature and then proceeded to discuss the findings narratively. Tables were then constructed and articles were sorted according to authors, year, title, location of study, sample size, psychiatric disorder, the aim of the study, principal findings, implications.
RESULTS: Twenty papers were identified as eligible, among which 2 articles on Schizophrenia, 1 on Autism Spectrum Disorders, 2 on Depression, 1 on Depression and Trauma-related Disorders, 1 on Depression and Anxiety, 2 on Anxiety and Sleep Disorders, 8 on Sleep Disorders, 2 on Alcohol use disorder and 1 on Cocaine Use Disorder.
CONCLUSIONS: This review suggests a correlation between the glymphatic system and several psychiatric disorders: Schizophrenia, Depression, Anxiety Disorders, Sleep Disorders, Alcohol Use Disorder, Cocaine Use Disorder, Trauma-Related Disorders, and Autism Spectrum Disorders. Impairment of the glymphatic system could play a role in Trauma-Related Disorders, Alcohol Use Disorders, Cocaine Use Disorders, Sleep Disorders, Depression, and Autism Spectrum Disorders. It is important to implement research on this topic and adopt standardized markers and radio diagnostic tools.