{Reference Type}: Journal Article
{Title}: Glymphatic System Dysfunction in Congenital Sensorineural Hearing Loss: A DTI-ALPS Study.
{Author}: Sha L;Xu ZG;Chen YC;
{Journal}: Curr Med Imaging
{Volume}: 0
{Issue}: 0
{Year}: 2024 Aug 2
暂无{DOI}: 10.2174/0115734056305276240730113140
{Abstract}: <B>BACKGROUND: </B>The neural mechanisms underlying congenital sensorineural hearing loss (CSNHL) remain elusive.<BR><B>OBJECTIVE: </B>This study evaluated the function of the glymphatic system in children with CSNHL compared to normal-hearing children using the DTI-ALPS approach, which utilizes diffusion tensor imaging along the perivascular space.<BR><B>METHODS: </B>Twenty-six children with CSNHL and 30 age- and sex-matched healthy controls (HCs) with normal hearing thresholds were recruited. The DTIALPS index was calculated for each group. We analyzed the discrepancies in the DTI-ALPS index between patients with CSNHL and healthy controls. Additionally, Spearman's correlation analysis was performed to investigate the relationship between the DTI-ALPS index and age in children with CSNHL.<BR><B>RESULTS: </B>Significant differences in the DTI-ALPS index were observed between the two groups. Compared with HCs, the DTI-ALPS index in CSNHL patients was significantly lower (1.49388±0.11441 vs. 1.61402±0.15430, p=0.002). In addition, diffusivity along the z-axis in the association fiber (Dzzassoc) index was significantly higher in the CSNHL group than in the HC group (0.00041±0.00006 vs. 0.00036±0.00004, p=0.003). Furthermore, we discovered a noteworthy downward correlation between the DTI-ALPS index and age in children with CSNHL (rho = -0.544, p=0.005).<BR><B>CONCLUSIONS: </B>In this present study, glymphatic system activity in CSNHL children was investigated for the first time using the DTI-ALPS index. A significant decrease in glymphatic system function was detected in CSNHL children, which correlated well with age. The DTI-ALPS index could serve as a valuable biomarker for tracking disease progression and treatment in CSNHL and unraveling the neural mechanisms of early hearing deprivation in children with CSNHL.