PDF(Pubmed)
Abstract：
The glymphatic system is cerebrospinal fluid-brain tissue fluid exchange flow mediated by aquaporin-4 (AQP4) on the end feet of astrocytes for a system, which is capable of rapidly removing brain metabolites and thus maintaining brain homeostasis, and is known as the central immune system. Dysfunction of the glymphatic system causes accumulation of misfolded and highly phosphorylated proteins (amyloid-β and Tau proteins), which destabilizes the proteins, and the body\'s neuroinflammatory factors are altered causing aging of the immune system and leading to neurodegenerative diseases. Damage to the glymphatic system and aging share common manifestations, as well as unstudied biological mechanisms that are also linked, such as mitochondria, oxidative stress, chronic inflammation, and sleep. In this paper, we first summarize the structure, function, and research methods of the glymphatic system and the relationship between the glymphatic system and the peripheral immune system, and second, sort out and summarize the factors of the glymphatic system in removing metabolites and resolving aging-related diseases and factors affecting aging, to explore its related biological mechanisms, and moreover, to provide a new way of thinking for treating or intervening aging-related diseases.
摘要：
淋巴系统是由星形胶质细胞末端脚上的水通道蛋白4（AQP4）介导的脑脊液-脑组织液体交换流，能够快速去除脑代谢物，从而维持脑稳态，被称为中枢免疫系统。淋巴系统的功能障碍导致错误折叠和高度磷酸化的蛋白质（淀粉样蛋白-β和Tau蛋白）的积累，这会破坏蛋白质的稳定性，和身体的神经炎症因子被改变，导致免疫系统老化并导致神经退行性疾病。对淋巴系统的损害和衰老有共同的表现，以及未经研究的生物学机制，比如线粒体，氧化应激，慢性炎症，和睡眠。在本文中,我们首先总结一下结构，函数,以及类淋巴系统和周围免疫系统之间关系的研究方法，第二,梳理总结了糖淋巴系统清除代谢产物、解决衰老相关疾病的因素和影响衰老的因素,探索其相关的生物学机制，而且,为治疗或干预衰老相关疾病提供新的思路。
