■肌肉减少症定义为肌肉功能以及肌肉质量的下降。肌肉减少症本身和肌肉减少性肥胖,定义为肥胖患者的肌肉减少症,已被用作结直肠癌预后较差的替代药物。这篇综述旨在确定是否有证据表明少肌症作为结直肠癌肝转移(CRLM)的预后参数。
■PubMed,Embase,CochraneCentral,WebofScience,Scopus,我们在CINAHL数据库中搜索了根据PRISMA指南选择的文章.主要结果是总生存期(OS)和无病生存期(DFS)。进行随机效应荟萃分析。
■消除重复项并筛选摘要(n=111)后,筛选了949项研究,33份出版物符合纳入标准。其中,15个是经过密切的论文审查后选出的,和10个被纳入荟萃分析,其中包括825名患者。肌少症对OS无显著影响(比值比(OR),2.802(95%置信区间(CI),1.094-1.11);p=0.4)或DFS(OR,发现1.203(95%CI,1.162-1.208);p=0.5),尽管有明显的肌少症趋势。肌肉减少显著影响术后并发症发生率(OR,7.905(95%CI,1.876-3.32);p=0.001)在两项数据可用的研究中。
■存在关于肌少症对接受CRLM切除术的患者的术后OS和DFS的影响的现有证据。在我们的分析中,我们无法确认肌少症患者的OS和DFS明显更差,尽管这一假设的趋势是可见的。肌肉减少症似乎会影响并发症的发生率,但需要进行前瞻性研究。
UNASSIGNED: Sarcopenia is defined as a decline in muscle function as well as muscle mass. Sarcopenia itself and sarcopenic obesity, defined as sarcopenia in obese patients, have been used as surrogates for a worse prognosis in colorectal cancer. This
review aims to determine if there is evidence for sarcopenia as a prognostic parameter in colorectal liver metastases (CRLM).
UNASSIGNED: PubMed, Embase, Cochrane Central, Web of Science, SCOPUS, and CINAHL databases were searched for articles that were selected in accordance with the PRISMA guidelines. The primary outcomes were overall survival (OS) and disease-free survival (DFS). A random effects meta-analysis was conducted.
UNASSIGNED: After eliminating duplicates and screening abstracts (n = 111), 949 studies were screened, and 33 publications met the inclusion criteria. Of them, 15 were selected after close paper
review, and 10 were incorporated into the meta-analysis, which comprised 825 patients. No significant influence of sarcopenia for OS (odds ratio (OR), 2.802 (95% confidence interval (CI), 1.094-1.11); p = 0.4) or DFS (OR, 1.203 (95% CI, 1.162-1.208); p = 0.5) was found, although a trend was defined toward sarcopenia. Sarcopenia significantly influenced postoperative complication rates (OR, 7.905 (95% CI, 1.876-3.32); p = 0.001) in two studies where data were available.
UNASSIGNED: Existing evidence on the influence of sarcopenia on postoperative OS as well as DFS in patients undergoing resection for CRLM exists. We were not able to confirm that sarcopenic patients have a significantly worse OS and DFS in our analysis, although a trend toward this hypothesis was visible. Sarcopenia seems to influence complication rates but prospective studies are needed.