PDF(Pubmed)
Abstract：
UNASSIGNED: The prognostic significance of lactate dehydrogenase (LDH) and its impact on the outcomes of gastric cancer (GC) is still unclear. We assessed the link between the levels of LDH and the overall survival (OS) and disease-free survival (DFS) in GC patients.
UNASSIGNED: A comprehensive search (both electronic and manual) was carried out in PubMed via MEDLINE, Web of Science (WoS), Experta Medical Database (Embase), and CENTRAL (Cochrane Library) databases for citations that evaluated the strength of association between LDH cut-off levels and OS and/or DFS in GC. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using a random-effects model, and heterogeneity was assessed.
UNASSIGNED: Eighteen studies with 5328 patients were included in our review. The overall pooled HR for OS was 1.48 (95% CI: 1.22-1.80) with high heterogeneity (I2 = 86%). Subgroup analyses showed that the link between LDH and OS was more prominent in Caucasian (HR 1.50 95% CI [0.80, 2.81], p=0.21) than in Asian cohorts (HR, 1.51 95% CI [1.21, 1.87], p=0.002). No significant overall association between LDH and OS (HR = 1.12, 95% CI: 0.76-1.65, p = 0.58) was found. Similar subgroup analyses results were reported for the association between LDH and DFS.
UNASSIGNED: In patients with GC, elevated LDH levels may correlate with worse OS and DFS, but the association is not significant. LDH is a significant predictor of OS but not of DFS. Further studies with larger sample sizes and more standardized criteria for defining elevated LDH levels are needed to confirm our findings.
UNASSIGNED: https://www.crd.york.ac.uk/prospero, identifier CRD42023412449.
UNASSIGNED: A comprehensive search (both electronic and manual) was carried out in PubMed via MEDLINE, Web of Science (WoS), Experta Medical Database (Embase), and CENTRAL (Cochrane Library) databases for citations that evaluated the strength of association between LDH cut-off levels and OS and/or DFS in GC. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using a random-effects model, and heterogeneity was assessed.
UNASSIGNED: Eighteen studies with 5328 patients were included in our review. The overall pooled HR for OS was 1.48 (95% CI: 1.22-1.80) with high heterogeneity (I2 = 86%). Subgroup analyses showed that the link between LDH and OS was more prominent in Caucasian (HR 1.50 95% CI [0.80, 2.81], p=0.21) than in Asian cohorts (HR, 1.51 95% CI [1.21, 1.87], p=0.002). No significant overall association between LDH and OS (HR = 1.12, 95% CI: 0.76-1.65, p = 0.58) was found. Similar subgroup analyses results were reported for the association between LDH and DFS.
UNASSIGNED: In patients with GC, elevated LDH levels may correlate with worse OS and DFS, but the association is not significant. LDH is a significant predictor of OS but not of DFS. Further studies with larger sample sizes and more standardized criteria for defining elevated LDH levels are needed to confirm our findings.
UNASSIGNED: https://www.crd.york.ac.uk/prospero, identifier CRD42023412449.
摘要：
■乳酸脱氢酶（LDH）的预后意义及其对胃癌（GC）预后的影响尚不清楚。我们评估了GC患者LDH水平与总生存期（OS）和无病生存期（DFS）之间的联系。
■通过MEDLINE在PubMed中进行了全面搜索（电子和手册），WebofScience(WoS),Experta医学数据库(Embase),和CENTRAL（CochraneLibrary）数据库，用于评估LDH截止水平与GC中的OS和/或DFS之间的关联强度。使用随机效应模型计算具有95%置信区间(CI)的集合风险比(HR)，并对异质性进行了评估。
■18项5328例患者的研究纳入我们的综述。OS的总合并HR为1.48（95％CI：1.22-1.80），具有高度异质性（I2=86％）。亚组分析显示，LDH和OS之间的联系在高加索人中更为突出(HR1.5095%CI[0.80,2.81]，p=0.21)比亚洲队列(HR，1.5195%CI[1.21，1.87]，p=0.002)。LDH和OS之间没有显著的相关性(HR=1.12,95%CI:0.76-1.65,p=0.58)。对于LDH和DFS之间的关联，报告了类似的亚组分析结果。
■在GC患者中，LDH水平升高可能与OS和DFS恶化相关，但关联并不重要。LDH是OS的重要预测因子，但不是DFS的重要预测因子。需要进一步研究更大的样本量和更标准化的定义LDH水平升高的标准来证实我们的发现。
■https://www.crd.约克。AC.英国/普劳里,标识符CRD42023412449。
■通过MEDLINE在PubMed中进行了全面搜索（电子和手册），WebofScience(WoS),Experta医学数据库(Embase),和CENTRAL（CochraneLibrary）数据库，用于评估LDH截止水平与GC中的OS和/或DFS之间的关联强度。使用随机效应模型计算具有95%置信区间(CI)的集合风险比(HR)，并对异质性进行了评估。
■18项5328例患者的研究纳入我们的综述。OS的总合并HR为1.48（95％CI：1.22-1.80），具有高度异质性（I2=86％）。亚组分析显示，LDH和OS之间的联系在高加索人中更为突出(HR1.5095%CI[0.80,2.81]，p=0.21)比亚洲队列(HR，1.5195%CI[1.21，1.87]，p=0.002)。LDH和OS之间没有显著的相关性(HR=1.12,95%CI:0.76-1.65,p=0.58)。对于LDH和DFS之间的关联，报告了类似的亚组分析结果。
■在GC患者中，LDH水平升高可能与OS和DFS恶化相关，但关联并不重要。LDH是OS的重要预测因子，但不是DFS的重要预测因子。需要进一步研究更大的样本量和更标准化的定义LDH水平升高的标准来证实我们的发现。
■https://www.crd.约克。AC.英国/普劳里,标识符CRD42023412449。
