%0 Journal Article
%T The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis.
%A Matly A
%A Quinn JA
%A McMillan DC
%A Park JH
%A Edwards J
%J Crit Rev Oncol Hematol
%V 163
%N 0
%D Jul 2021
%M 33992802
%F 6.625
%R 10.1016/j.critrevonc.2021.103337
%X β-catenin is a key component of Wnt signalling, which plays a crucial role in CRC progression. Therefore, a meta-analysis was performed to assess the prognostic value of β-catenin expression in CRC patients. PubMed and Web of Science were searched for relevant publications referring to the association between β-catenin expression and outcome of CRC patients. Review Manager version 5.4 was employed to analysis data from 28 eligible studies (containing 5475 patients). Of these, 6 provided data on DFS, 6 provided data on CSS and 18 reports provided data on OS. High nuclear β-catenin expression was significantly associated with poorer DFS, CSS and OS in patients with CRC whereas, low membranous β-catenin expression was associated to poor OS. In conclusion, β-catenin has prognostic value and potential as a biomarker to stratify patients with CRC. However, further work with high quantity tissue cohorts and patient data is required to confirm this conclusion.