dietary patterns

膳食模式
  • 文章类型: Journal Article
    目的:我们旨在利用主成分分析(PCA)和营养几何框架(GFN)探讨孕前6个月饮食模式与妊娠期糖尿病(GDM)的关系。
    方法:我们进行了一项病例对照研究,包括210名GDM孕妇和210名对照。通过验证的半定量食物频率问卷(FFQ)评估所有参与者的饮食摄入量。主要膳食模式由PCA提取。使用条件逻辑回归模型来确定特定的饮食模式是否与GDM的风险相关。同时,使用GFN可视化了饮食模式与GDM之间的关系。
    结果:确定了四种主要的膳食模式:富含蛋白质的模式,“\”基于植物的模式,“\”油-泡菜-甜点模式,“和”谷物坚果模式。“在对混杂因素进行调整后,“基于植物的模式”与GDM风险降低相关(第四季度与Q1:OR=0.01,95%CI:0.00-0.08),而在其他饮食模式中没有发现显著关联。此外,人们没有饮食摄入冰淇淋锥和油炸面团棒,这将产生更少的GDM患者。油条在病例组和对照组中差异有统计学意义(p<0.001),而冰淇淋蛋卷却有相反的结果。
    结论:“基于植物的模式”可以降低GDM的风险。此外,虽然“谷物-坚果模式”与GDM风险没有关联,避免油条的摄入可以降低GDM的风险。
    OBJECTIVE: We aimed to explore the relationship between dietary patterns and gestational diabetes mellitus (GDM) during pre-pregnancy six months using principal component analysis (PCA) and the geometric framework for nutrition (GFN).
    METHODS: We conducted a case-control study that included 210 GDM pregnant women and 210 controls. The dietary intake of all participants was assessed by a validated semi-quantitative food frequency questionnaire (FFQ). Major dietary patterns were extracted by PCA. A conditional logistic regression model was used to determine whether specific dietary patterns are associated with the risk of GDM. Meanwhile, the relationship between dietary patterns and GDM was visualized using GFN.
    RESULTS: Four major dietary patterns were identified: \"protein-rich pattern,\" \"plant-based pattern,\" \"oil-pickles-desserts pattern,\" and \"cereals-nuts pattern.\" After adjustment for confounders, the \"plant-based pattern\" was associated with decreased risk of GDM (Q4 vs. Q1: OR = 0.01, 95% CI: 0.00-0.08), whereas no significant association was found in other dietary patterns. Moreover, there was no dietary intake of ice cream cones and deep-fried dough sticks for the population, which would produce fewer patients with GDM. Deep-fried dough sticks had statistically significant differences in the case and control groups (p < 0.001), while ice cream cones had the opposite result.
    CONCLUSIONS: The \"plant-based pattern\" may reduce the risk of GDM. Besides, although the \"cereals-nuts pattern\" had no association with GDM risk, avoiding the intake of deep-fried dough sticks could decrease GDM risk.
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  • 文章类型: Journal Article
    全球饮食数据储存库是营养监测的关键组成部分。两个最全面的数据库,全球膳食数据库(GDD)和全球负担疾病(GBD),提供国家膳食摄入量估计值,但使用不同的数据源和模型来生成估计值。为了探索GDD和GBD估计之间的协议,我们使用描述性统计比较了169个国家在28年期间的特定国家的平均每日钠摄入量,Bland-Altman方法,和患病率超过2.3克/天的摄入量参考水平。我们检测到GDD和GBD估计的全球平均摄入量之间存在惊人的36%差异(2.68±0.74与3.88±1.15g/天,分别为;p<0.0001)。由于104个(61.5%)国家报告这两个数据库都过度消耗钠,制定国家膳食摄入量评估的标准化方法对于以系统和全面的方式监测全球钠摄入量以及实施减少钠摄入量的全球战略至关重要。
    Global dietary data repositories are key components of nutrition surveillance. The two most comprehensive databases, the Global Dietary Database (GDD) and the Global Burden Disease (GBD), provide national dietary intake estimates but use different data sources and models to generate estimates. To explore the agreement between GDD and GBD estimates, we compared country-specific average daily sodium intakes in 169 countries over a 28-year period using descriptive statistics, the Bland-Altman method, and prevalence exceeding the intake reference level of 2.3 g/day. We detected a staggering 36% difference between GDD and GBD estimates of global mean intakes (2.68 ± 0.74 vs. 3.88 ± 1.15 g/day, respectively; p < 0.0001). As 104 (61.5%) countries reported to have over-consumed sodium by both databases, the development of standardized approaches for national dietary intake estimation is critical for monitoring global sodium intake in a systematic and comprehensive way and for implementing global strategies to reduce sodium intake.
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  • 文章类型: Journal Article
    背景:有限的研究报道了饮食模式与幽门螺杆菌之间的关联(H.幽门螺杆菌)沙巴感染。
    目的:本研究的目的是评估2021年在伊丽莎白女王医院(QEH)进行首次食管胃十二指肠镜检查(OGDS)的18岁及以上患者的饮食模式与幽门螺杆菌感染之间的关系。KotaKinabalu.
    方法:使用2014年马来西亚成人营养调查(MANS)改编的问卷,将阳性幽门螺杆菌的饮食摄入量与健康受试者进行比较。使用逻辑回归模型,我们评估了饮食模式与幽门螺杆菌感染风险之间的关系.
    结果:我们的发现确定了四种饮食模式,即“高碳水化合物模式”,“高纤维图案”,“高脂肪/胆固醇模式”和“高盐模式”。在调整了潜在的混杂因素后,“高盐模式”的最高四分位数显示幽门螺杆菌感染的几率(OR=1.26;95%Cl:1.032-1.459;P=0.045)比最低四分位数更大,而“高纤维图案”的最高四分位数显示出比最低四分位数更低的感染奇数(OR=0.69;95%Cl:0.537-0.829;P=0.008)。如果与2017年推荐营养素摄入量(RNI)相比,幽门螺杆菌阳性消耗高碳水化合物和钠,纤维摄入量不足。
    结论:总而言之,“高纤维模式”降低幽门螺杆菌感染的风险,而“高盐模式”增加感染风险。我们的研究还强调了每日摄入营养素的重要性。
    BACKGROUND: Limited studies have reported the association between dietary patterns and Helicobacter pylori (H. pylori) infection in Sabah.
    OBJECTIVE: The purpose of this study was to assess the association between dietary pattern and H. pylori infection among patients aged 18 years and above that went for first esophagogastroduodenoscopy (OGDS) in 2021 at Queen Elizabeth Hospital (QEH), Kota Kinabalu.
    METHODS: Dietary intake of positive H. pylori was compared with healthy subjects by using questionnaire adapted from Malaysian Adult Nutrition Survey (MANS) 2014. Using logistic regression models, we evaluated the association between dietary pattern and H. pylori infection risk.
    RESULTS: Our finding identified four dietary patterns, namely \"high carbohydrate pattern\", \"high fiber pattern\", \"high fat/cholesterol pattern\" and \"high salt pattern\". After adjustment for potential confounders, the highest quartile of \"high salt pattern\" showed greater odds of H. pylori infection (OR = 1.26; 95% Cl: 1.032-1.459; P = 0.045) than lowest quartile, while highest quartile of \"high fiber pattern\" demonstrated lower odd of the infection (OR = 0.69; 95% Cl: 0.537-0.829; P = 0.008) than those in lowest quartile. If compared with Recommended Nutrient Intake (RNI) 2017, positive H. pylori consumed high carbohydrates and sodium with insufficient fiber intake.
    CONCLUSIONS: To conclude, \"high fiber pattern\" lowers the risk of H. pylori infection while \"high salt pattern\" increases the infection risk. Our study also highlighted the importance of nutrient intake within daily allowances.
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  • 文章类型: Journal Article
    饮食模式可能是结直肠癌(CRC)风险的关键可改变因素。这项研究旨在研究韩国两种方法得出的饮食模式与CRC风险的关系。在一项对1420例CRC患者和2840例对照参与者的研究中,我们使用33种预定义的食物组,通过主成分分析(PCA)和降阶回归(RRR)获得了膳食模式.使用非条件逻辑回归模型评估饮食模式与CRC风险之间的关联,以计算优势比(ORs)和95%置信区间(CIs)。我们确定了两种相似的饮食模式,从PCA1(谨慎)和RR(健康)得出,其特点是绿色/黄色蔬菜的消费量较高,浅色蔬菜,水果,鸡蛋,和牛奶在男人和女人。在女性中,较高的谨慎和健康模式得分与较低的CRC风险显著相关(谨慎,ORQ4vs.Q1=0.59,95%CI0.40-0.86,趋势P=0.005;健康,ORQ4vs.Q1=0.62,95%CI0.43-0.89,趋势P=0.007)。在男人中,仅在健康饮食模式下,饮食模式与直肠癌风险之间存在显著的负相关(ORQ4与Q1=0.66,95%CI0.45-0.97,趋势P=0.036)。与PCA得出的膳食模式相比,RRR饮食模式与远端结肠癌风险较低的相关性稍强(ORQ4与Q1=0.58,95%CI0.35-0.97,趋势P=0.025)和直肠癌(ORQ4与Q1=0.29,95%CI0.15-0.57,趋势P<0.001)。我们的研究结果表明,癌症预防策略侧重于富含蔬菜的饮食,水果,鸡蛋,和牛奶。此外,PCA和RRR方法的使用可能有利于探索饮食模式与CRC风险之间的关联.
    Dietary patterns may be a crucial modifiable factor in colorectal cancer (CRC) risk. This study aimed to examine the associations of dietary patterns derived from two methods with CRC risk in Korea. In a study of 1420 CRC patients and 2840 control participants, we obtained dietary patterns by principal component analysis (PCA) and reduced rank regression (RRR) using 33 predefined food groups. The associations between dietary patterns and CRC risk were assessed using unconditional logistic regression models to calculate odds ratios (ORs) and 95% confidence intervals (CIs). We identified two similar dietary patterns, derived from PCA 1 (prudent) and RRR (healthy), characterized by higher consumption of green/yellow vegetables, light-colored vegetables, fruits, eggs, and milk in both men and women. In women, higher prudent and healthy pattern scores were significantly associated with a lower risk of CRC (prudent, ORQ4 vs. Q1 = 0.59, 95% CI 0.40-0.86, P for trend = 0.005; healthy, ORQ4 vs. Q1 = 0.62, 95% CI 0.43-0.89, P for trend = 0.007). In men, a significant inverse association between dietary pattern and risk of rectal cancer was found only for the healthy dietary pattern (ORQ4 vs. Q1 = 0.66, 95% CI 0.45-0.97, P for trend = 0.036). Compared with the dietary pattern derived by PCA, the RRR dietary pattern had a slightly stronger association with a lower risk of distal colon cancer (ORQ4 vs. Q1 = 0.58, 95% CI 0.35-0.97, P for trend = 0.025) and rectal cancer (ORQ4 vs. Q1 = 0.29, 95% CI 0.15-0.57, P for trend < 0.001) in women. Our findings suggest cancer prevention strategies focusing on a diet rich in vegetables, fruits, eggs, and milk. Moreover, the use of both PCA and RRR methods may be advantageous to explore the associations between dietary patterns and risk of CRC.
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  • 文章类型: Journal Article
    背景:饮食摄入是非酒精性脂肪性肝病(NAFLD)的发展和管理的重要因素,最佳食物组组成仍不清楚。来自印度的NAFLD患者的详细食物组摄入量数据很少。
    方法:在这项研究中,有320名参与者(160名NAFLD病例和160名对照),在过去一年中,我们使用为期2天的24小时饮食回顾和经过验证的142项食物频率问卷评估了饮食习惯.主成分分析确定了参与者中与NAFLD相关的饮食模式。
    结果:与对照组相比,病例对食用油和脂肪以及坚果和油籽的摄入量明显更高(p<0.05)。食用油和脂肪与NAFLD呈正相关且显着相关[OR(95%CI):1.7(1.11-2.49)p=0.013)。在膳食模式分析中,发现西方膳食模式是NAFLD的风险,而保护性膳食模式与NAFLD的风险降低相关。
    结论:NAFLD病例和对照组的总食物组摄入量较低,提示饮食质量较低。发现保护性膳食模式对NAFLD有益。与西方饮食模式相关的高摄入糖和食用油会增加NAFLD的风险。
    Dietary intake is an important factor in the development and management of non-alcoholic fatty liver disease (NAFLD) however, optimal food group composition remains unclear. Data on detailed food group intake of NAFLD patients from India is scarce.
    In this study with 320 participants (160 NAFLD cases and 160 controls), dietary habits were assessed using a 24-h dietary recall for two days and a validated 142-item food frequency questionnaire over the past year. Principal component analysis identified dietary patterns associated with NAFLD among the participants.
    Cases were having a significantly higher intake of edible oils and fats along with nuts and oilseeds as compared to controls (p < 0.05). There was a positive and significant association with edible oils and fats with NAFLD [OR (95 % CI):1.7 (1.11-2.49) p = 0.013). In dietary pattern analysis western dietary pattern was found to be a risk for NAFLD whereas protective dietary pattern was associated with the decreased risk of NAFLD.
    The overall food groups intake in NAFLD cases and controls was low suggesting lower diet quality. Protective dietary pattern found to be beneficial for NAFLD. High intake of sugars and edible oils associated with western dietary pattern increases the risk of NAFLD.
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  • 文章类型: Journal Article
    本研究旨在检查膳食模式之间的关联,生活方式因素,马来西亚人群中的大肠癌(CRC)风险。
    我们从两家选定的政府医院招募了100名患者和100名对照。使用123项半定量食物频率问卷,使用主成分分析来确定饮食模式。根据WHOSTEPS调查问卷修改了吸烟和饮酒问卷。使用修订后的全球身体活动问卷评估身体活动水平。膳食模式之间的关联,生活方式因素和CRC风险使用SPSS版本24.0的logistic回归进行评估.
    从因子分析中得出三种饮食模式:i)蔬菜;ii)肉类,海鲜和加工食品;和iii)谷物和豆类。高蔬菜饮食摄入与CRC风险降低81%独立且显著相关(比值比[OR]:0.19;95%置信区间[CI]:0.08,0.46)。与娱乐相关的体力活动(OR:2.04;95%CI:1.14,3.64)和剧烈的体力活动(OR:2.06;95%CI:1.13,3.74)均与CRC风险降低显着相关。每天吸烟数量(≥16支香烟)的增加显着增加了发生CRC的几率(OR:2.58;95%CI:1.95,6.75)。停止饮酒的持续时间与CRC风险呈负相关(OR:2.52;95%CI:2.30,10.57)。
    水果和蔬菜饮食的保护作用,健康的生活方式可用于制定有助于降低马来西亚人群CRC风险的干预措施.
    UNASSIGNED: This study aimed to examine the association between dietary patterns, lifestyle factors, and colorectal cancer (CRC) risk among the Malaysian population.
    UNASSIGNED: We recruited 100 patients and 100 controls from two selected government hospitals. Principal component analysis was used to identify dietary patterns using a 123-item semiquantitative food frequency questionnaire. Tobacco smoking and alcohol consumption questionnaires were modified from the WHO STEPS Survey questionnaire. Physical activity levels were assessed using the revised Global Physical Activity questionnaire. Associations between dietary patterns, lifestyle factors and CRC risk were assessed using logistic regression with SPSS version 24.0.
    UNASSIGNED: Three dietary patterns were derived from factor analysis: i) vegetables; ii) meat, seafood and processed food; and iii) grains and legumes. High vegetable diet intake was independently and significantly associated with an 81% decreased risk of CRC (odds ratio [OR]: 0.19; 95% confidence interval [CI]: 0.08, 0.46). Both recreational-related physical activity (OR: 2.04; 95% CI: 1.14, 3.64) and vigorous physical activity (OR: 2.06; 95% CI: 1.13, 3.74) are significantly associated with decreased risk of CRC. Increasing the number of cigarettes smoked (≥ 16 cigarettes) per day significantly increased the odds of developing CRC (OR: 2.58; 95% CI: 1.95, 6.75). The duration of alcohol consumption cessation was inversely associated with CRC risk (OR: 2.52; 95% CI: 2.30, 10.57).
    UNASSIGNED: The protective effects of a fruit and vegetable diet, and a healthy lifestyle can be used to develop interventions that help reduce the risk of CRC in the Malaysian population.
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  • 文章类型: Journal Article
    背景:在发展中国家和不发达国家,营养不良在颠覆免疫系统中起着重要作用,本研究调查了上海年轻人的膳食模式与潜伏性结核感染风险之间的关系。
    方法:在一项病例对照研究中,从2021年1月至2023年3月,在大学结核病流行集中的学生接触者中研究了96例潜伏性结核病感染和192例健康对照。评估社会人口统计学的标准化问卷,生活方式,并应用了饮食特征。使用95项半定量食物频率问卷估算食物摄入量。使用主成分分析从食物组摄入量中提取膳食模式。采用Logistic回归模型。
    结果:确定了四种饮食模式:“传统平衡”模式,“不饱和脂肪酸”模式,“零食”模式,和“蛋白质和水果”模式。得出了解释消费总变化64.52%的四个组成部分。在条件逻辑回归分析中,创建了三个模型。在调整了各种混杂因素后,与“小吃”模式相比,在“传统平衡”模式下,潜伏性结核感染的风险降低了91%(OR0.05,95%CI0.01,0.38,p=0.004)。
    结论:为了预防生活在高结核病负担地区的年轻人的结核病感染,在学校环境中应该提倡均衡的饮食模式,而不是“零食”模式。未来的研究应探讨不同膳食模式的Mtb感染者患活动性结核病的风险,并通过健康的膳食模式预防这种风险。
    BACKGROUND: In developing and underdeveloped countries, undernutrition plays a major role in subverting the immune system, leading to an increase in TB infections; this study investigated the associations between dietary patterns and latent tuberculosis infection risk among young adults in Shanghai.
    METHODS: In a case-control study, 96 cases of latent tuberculosis infection and 192 healthy controls were studied among contacts of students in clusters of tuberculosis epidemics in colleges from January 2021 to March 2023. A standardized questionnaire assessing sociodemographic, lifestyle, and dietary characteristics was applied. Food intake was estimated using a 95-item semiquantitative Food Frequency Questionnaire. Using the principal component analysis to extract dietary patterns from food groups intake. Logistic regression models were applied.
    RESULTS: Four dietary patterns were identified: \"traditional balanced\" pattern, \"unsaturated fatty acid\" pattern, \"snack\" pattern, and \"protein and fruit\" pattern. Four components explaining 64.52% of the total variation in consumption were derived. In a conditional logistic regression analysis, three models were created. After adjusting for various confounders, compared to \"snack\" pattern, the risk of latent TB infection was 91% lower in the \"traditional balanced\" pattern (OR 0.05, 95% CI 0.01, 0.38, p = 0.004).
    CONCLUSIONS: To prevent TB infection among young adults living in high TB burden areas, a balanced dietary pattern rather than a \"snack\" pattern should be promoted in school settings. Future research should explore the risk of developing active tuberculosis in Mtb-infected people with different dietary patterns and the prevention of this risk by healthy dietary patterns.
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  • 文章类型: Journal Article
    背景:饮食摄入对性早熟的作用尚不清楚。本研究旨在调查中国女孩膳食摄入量和频率与性早熟风险之间的关系。
    方法:在本病例对照研究中,我们纳入了185名性早熟女孩和185名年龄匹配的对照.通过半定量食物频率问卷评估他们的饮食摄入量。收集了他们的社会人口统计学和生活方式数据。通过条件logistic回归模型评估饮食摄入与性早熟风险之间的关系。
    结果:经过多变量调整后,食用大量红肉与性早熟风险较高相关(OR=2.74,95%CI:1.25-6.02),而较高的水果频率(趋势P=0.024)和蔬菜摄入量与较低的性早熟风险相关(趋势P=0.002)。高植物蛋白膳食模式与性早熟呈显著负相关(OR=0.78,95%CI:0.63-0.97),而高动物性食物和水果的膳食模式与性早熟呈显著正相关(OR=1.36,95%CI:1.09-1.69),在调整了年龄和体重指数后。
    结论:高蔬菜和蛋白质的膳食模式是防止性早熟的保护因素,而高动物性食物和水果的饮食模式是中国女孩性早熟的危险因素。应该注意合理摄入红肉,鸡蛋,和水果在儿童的日常饮食,增加他们的蔬菜摄入量,以降低性早熟的风险。
    BACKGROUND: The role of dietary intake on precocious puberty remains unclear. This study aimed to investigate the association between the amount and frequency of dietary intake and the risk of precocious puberty in Chinese girls.
    METHODS: In this case-control study, we enrolled 185 precocious puberty girls and 185 age-matched controls. Their dietary intake was assessed through a semi-quantitative food frequency questionnaire. Their sociodemographic and lifestyle data were collected. The associations between dietary intake and risk of precocious puberty were assessed by conditional logistic regression models.
    RESULTS: After multivariate adjustment, consuming a higher amount of red meat was associated with higher precocious puberty risk (OR = 2.74, 95% CI: 1.25-6.02), while a higher frequency of fruit ( P for trend = 0.024) and amount of vegetable intake was associated with a lower risk of precocious puberty (P for trend = 0.002). The high vegetable and protein dietary pattern was significantly negatively associated with precocious puberty (OR = 0.78, 95% CI: 0.63-0.97), whereas the high animal food and fruits dietary pattern was remarkably positively associated with precocious puberty (OR = 1.36, 95% CI: 1.09-1.69), after adjusting for age and body mass index.
    CONCLUSIONS: High vegetable and protein dietary pattern is a protective factor against precocious puberty, while high animal food and fruits dietary pattern is a risk factor for precocious puberty in Chinese girls. Attentions should be paid to a reasonable intake of red meat, eggs, and fruits in children\'s daily diet, increase their intake of vegetables, in order to reduce the risk of precocious puberty.
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  • 文章类型: Journal Article
    这项研究的主要目的是使用数据驱动的方法分析饮食模式,并探索肾结石疾病(KSD)的预防或危险饮食因素。在上海郊区的成年人(n=6396)中进行了病例对照匹配研究。食物频率问卷被用来评估各类食物的消费量,用B超鉴别肾结石。采用主成分分析和回归方法生成膳食模式,并进一步探讨膳食模式与KSD的关系。使用LASSO回归和选择后推断来识别与KSD最相关的食物组。在男性中,“平衡但不含糖的饮料模式”(OR=0.78,p<0.05)和“坚果和泡菜模式”(OR=0.84,p<0.05)是保护性饮食模式。在女性中,“高蔬菜和低糖饮料模式”(OR=0.83,p<0.05)和“高甲壳类和低蔬菜模式”(OR=0.79,p<0.05)是保护性饮食模式,而“偏爱肉类的综合模式”(OR=1.06,p<0.05)和“含糖饮料模式”(OR=1.16,p<0.05)是风险饮食模式。我们进一步推断含糖饮料(p<0.05)是危险因素,咸菜(p<0.05)和甲壳类动物(p<0.05)是保护因素。
    The main objective of this study was to analyze dietary patterns using data-driven approaches and to explore preventive or risk dietary factors for kidney stone disease (KSD). A case-control matching study was conducted in adults (n = 6396) from a suburb of Shanghai. A food frequency questionnaire was used to assess the consumption of various types of food, and B-ultrasound was used to identify kidney stones. Principal component analysis and regression were used to generate dietary patterns and further explore the relationship between dietary patterns and KSD. LASSO regression and post-selection inference were used to identify food groups most associated with KSD. Among males, the \"balanced but no-sugary-beverages pattern\" (OR = 0.78, p < 0.05) and the \"nuts and pickles pattern\" (OR = 0.84, p < 0.05) were protective dietary patterns. Among females, \"high vegetables and low-sugary-beverages pattern\" (OR = 0.83, p < 0.05) and \"high-crustaceans and low-vegetables pattern\" (OR = 0.79, p < 0.05) were protective dietary patterns, while the \"comprehensive pattern with a preference for meat\" (OR = 1.06, p < 0.05) and \"sugary beverages pattern\" (OR = 1.16, p < 0.05) were risk dietary patterns. We further inferred that sugary beverages (p < 0.05) were risk factors and pickles (p < 0.05) and crustaceans (p < 0.05) were protective factors.
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  • 文章类型: Journal Article
    多囊卵巢综合征(PCOS),作为育龄妇女最常见的内分泌疾病,受各种因素的影响。因为有证据表明炎症和慢性疾病有关,我们假设在成人人群中,饮食炎症模式评分(EDIP)与PCOS的几率之间存在相关关系.这项病例对照研究是针对伊朗的德黑兰妇女进行的。共有494名参与者(病例组203名PCOS女性,对照组291名健康人),18至45岁,被招募参加这项研究。人口统计信息,人体测量指数,身体活动水平,和饮食摄入量由训练有素的营养学家收集。计算EDIP评分以估计基于18个食物组的总体饮食炎症潜能。使用SPSS版本19进行统计学分析。根据结果,病例组和对照组的平均年龄分别为28.98±5.43和30.15±6.21岁,分别。与健康参与者相比,PCOS患者的EDIP评分差异显著(2.03±1.13vs1.70±0.93,P<.001)。此外,EDIP四分位数间PCOS风险的比值比和95%置信区间显示出显著的直接关系(P=.003).总之,我们的研究表明,PCOS风险与EDIP评分有直接关联.研究结果表明,炎症指数可能是联系饮食和PCOS发展的潜在机制。
    Polycystic ovary syndrome (PCOS), as the most common endocrine disorder in women of reproductive age, is influenced by various factors. Because there is evidence linking inflammation with chronic diseases, we hypothesized that there is a relationship between an empirical dietary inflammatory pattern score (EDIP) with odds of PCOS among the adult population. This case control study was conducted on Tehranian women in Iran. A total of 494 participants (203 women with PCOS in the case group and 291 healthy people in the control group), aged 18 to 45 years, were recruited for the study. Demographic information, anthropometric indices, physical activity level, and dietary intake were collected by a trained nutritionist. EDIP score was calculated to estimate overall dietary inflammatory potential based on 18 food groups. Statistical analysis was performed with SPSS version 19. Based on the results, the mean age of participants in the case and control groups were 28.98 ± 5.43 and 30.15 ± 6.21 years, respectively. Individuals with PCOS had a significantly higher difference in EDIP score compared with healthy participants (2.03 ± 1.13 vs 1.70 ± 0.93, P < .001). Also, the odds ratio and 95% confidence interval for the risk of PCOS across quartiles of EDIP showed a significant direct relationship (P = .003). In conclusion, our study showed that there was a direct association between PCOS risk and EDIP score. Findings suggest that inflammatory index might be a potential mechanism linking diet and PCOS development.
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