抑郁症是年轻人疾病负担的主要原因。在这项研究中,我们旨在评估抑郁症状升高对身体健康相关生活质量的影响。
■我们使用了来自BELLA前瞻性队列研究的自我报告信息,其中包括从德国普通人群中选择的青少年。基线评估(2003-2006年)和1-,2-,6年的随访波提供了数据基础。
■基线研究人群包括1,460名12至17岁的青少年,据他们的照顾者说,没有患抑郁症。
■主要结果,根据6年随访时SF-36的身体成分评分(PCS)(范围:0-100),与身体健康相关的生活质量。感兴趣的暴露是抑郁症状,根据流行病学研究中心儿童抑郁量表(CES-DC)在基线测量,1年随访和2年随访(范围:0-60)。我们将暴露分为亚阈值(≤15)和抑郁症状(>15)。对于主要分析,我们考虑了三个时间点(范围:0-3)的抑郁症状升高的累积指数。被认为是性别的混杂因素,年龄,社会经济地位,移民背景,社会支持,焦虑症状,身体活动,慢性疾病,和睡眠问题。
■我们使用多重归集来解释缺失值。在每个估算的数据集中,我们应用逆概率加权(IPW)来估计基线时抑郁症状升高的累积指数的影响,在6年随访时,对身体健康相关生活质量进行1年和2年随访。我们通过自举得出95%的置信区间。
■用IPW调整后,抑郁症状升高每增加1个单位的累积指数对身体成分评分的影响为-1.71(95%CI:-3.51~-0.04).基线时,单一暴露的抑郁症状对身体健康相关生活质量的调整效应估计值为-0.83(95%CI:-3.69至1.87),1年随访时-2.96(95%CI:-4.94至-0.52),2年随访时-1.32(95%CI:-3.85至1.15)。
研究结果表明,青春期抑郁症状的升高会降低成年后与身体健康相关的生活质量。
UNASSIGNED: Depression is a major contributor of young people\'s burden of disease. In this
study we aim to estimate the effect of elevated depressive symptoms on physical health-related quality of life.
UNASSIGNED: We used self-reported information from the prospective BELLA cohort
study, which included adolescents selected from the general population in Germany. The baseline assessment (2003-2006) and the 1-, 2-, and 6-year follow-up waves provide the data basis.
UNASSIGNED: The baseline
study population consisted of 1,460 adolescents between the ages of 12 and 17 who, according to their caregivers, did not suffer from depression.
UNASSIGNED: The primary outcome, as measured by the physical component score (PCS) of the SF-36 at a 6-year follow-up (range: 0-100), is physical health-related quality of life. The exposure of interest is depressive symptoms, as measured by the Center for Epidemiological Studies Depression Scale for Children (CES-DC) at baseline, 1-year follow-up and 2-year follow-ups (range: 0-60). We dichotomized the exposure into subthreshold (≤15) and elevated depressive symptoms (>15). For the main analyses we considered a cumulative index for elevated depressive symptoms across the three time points (range: 0-3). Considered confounders are sex, age, socioeconomic status, migrant background, social support, anxiety symptoms, physical activity, chronic diseases, and sleeping problems.
UNASSIGNED: We used multiple imputation to account for missing values. Within each imputed dataset, we applied inverse probability weighting (IPW) to estimate the effect of the cumulative index for elevated depressive symptoms at baseline, 1- and 2-year follow-up on physical health-related quality of life at 6-year follow-up. We derived 95% confidence intervals by bootstrapping.
UNASSIGNED: After adjusting with IPW, the effect of the cumulative index per one unit increase of elevated depressive symptoms on the physical component score was -1.71 (95% CI: -3.51 to -0.04). The adjusted effect estimates of single exposure of elevated depressive symptoms on physical health-related quality of life were -0.83 (95% CI: -3.69 to 1.87) at baseline, -2.96 (95% CI: -4.94 to -0.52) at 1-year follow-up and -1.32 (95% CI: -3.85 to 1.15) at 2-year follow-up.
UNASSIGNED: Findings suggest that elevated depressive symptoms during adolescence decrease physical health-related quality of life in young adulthood.