目的:为了全面检查儿童和成年的身体大小的关联,儿童到成人的体型随成人白细胞端粒长度(LTL)的变化。
方法:我们包括来自英国生物库的453602名参与者。通过问卷收集10岁儿童的体型。使用体重指数(BMI)评估成人的体型,腰围(WC),腰臀比(WHR),脂肪质量指数(FMI),和无脂肪质量指数(FFMI)。
结果:儿童时期体型丰满的个体在成年期表现出更短的LTL(-0.0086[-0.0017,-0.0004])。成人BMI(-0.0286[-0.0315,-0.0258]),WC(-0.0271[-0.0303,-0.0238]),WHR(-0.0269[-0.0308,-0.0230])和FMI(-0.0396[-0.0438,-0.0351])与LTL呈负相关,而FFMI(0.0095[0.0039,0.0152])与LTL呈正相关。与在童年和成年期始终具有平均/正常体重的个体相比,那些从儿童到成年保持或发展为超重/肥胖的人成年LTL较短,不管童年的体型。值得注意的是,在儿童期体型较丰满但成年期体重正常的个体中未观察到LTL缩短效应。
结论:儿童和成年期肥胖都与成年期LTL缩短相关。从儿童到成年过渡到或保持超重/肥胖状态与较短的成年LTL有关,而如果儿童体重正常,这种效果可以逆转。
OBJECTIVE: To comprehensively examine the associations of
childhood and adulthood body size, and child-to-adult body size change with adult leucocyte telomere length (LTL).
METHODS: We included 453 602 participants from the UK Biobank.
Childhood body size at the age of 10 years was collected through a questionnaire. Adulthood body size was assessed using body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), fat mass index (FMI), and fat-free mass index (FFMI).
RESULTS: Individuals with plumper body size in
childhood exhibited shorter LTL in adulthood (-0.0086 [-0.0017, -0.0004]). Adulthood BMI (-0.0286 [-0.0315, -0.0258]), WC (-0.0271 [-0.0303, -0.0238]), WHR (-0.0269 [-0.0308, -0.0230]) and FMI (-0.0396 [-0.0438, -0.0351]) were negatively associated with LTL, whereas FFMI (0.0095 [0.0039, 0.0152]) was positively associated with LTL. Compared to individuals consistently having an average/normal weight in both
childhood and adulthood, those who maintained or developed overweight/obesity from childhood to adulthood had a shorter adult LTL, regardless of
childhood body size. Notably, the LTL shortening effect was not observed in individuals with plumper body size in childhood but normal weight in adulthood.
CONCLUSIONS: Childhood and adulthood obesity are both associated with LTL shortening in adulthood. Transitioning to or maintaining overweight/obese status from childhood to adulthood is associated with shorter adult LTL, whereas this effect can be reversed if plumper children become normal weight.