炎症是宿主抵抗有害外部刺激的保护性反应,有助于组织修复和重塑。然而,过度的炎症严重威胁着患者的生命。由于抗炎作用,皮质类固醇,免疫抑制剂,单克隆抗体用于治疗各种炎症性疾病,但是抗药性,无反应,严重的副作用限制了它们的发展和应用。因此,在抗炎治疗中,开发其他替代疗法已变得至关重要。近年来,干细胞的深入研究使其成为治疗炎症性疾病的有希望的替代药物,干细胞的功能受多种信号调节,其中多巴胺信号传导是主要影响因素之一。在这次审查中,我们回顾了多巴胺对各种成体干细胞(神经干细胞,间充质基质细胞,造血干细胞,和癌症干细胞)及其信号通路,以及一些关键的多巴胺受体激动剂/拮抗剂的应用。此外,我们还回顾了各种成体干细胞在炎症性疾病中的作用,并讨论了多巴胺受体的潜在抗炎功能,为再生医学治疗炎症性疾病提供了新的治疗靶点。
Inflammation is the host\'s protective response against harmful external stimulation that helps tissue repair and remodeling. However, excessive inflammation seriously threatens the patient\'s life. Due to anti-inflammatory effects, corticosteroids, immunosuppressants, and monoclonal antibodies are used to treat various inflammatory diseases, but drug resistance, non-responsiveness, and severe side effect limit their development and application. Therefore, developing other alternative therapies has become essential in anti-inflammatory therapy. In recent years, the in-depth study of stem cells has made them a promising alternative drug for the treatment of inflammatory diseases, and the function of stem cells is regulated by a variety of signals, of which dopamine signaling is one of the main influencing factors. In this
review, we
review the effects of dopamine on various adult stem cells (neural stem cells, mesenchymal stromal cells, hematopoietic stem cells, and cancer stem cells) and their signaling pathways, as well as the application of some critical dopamine receptor agonists/antagonists. Besides, we also
review the role of various adult stem cells in inflammatory diseases and discuss the potential anti-inflammation function of dopamine receptors, which provides a new therapeutic target for regenerative medicine in inflammatory diseases.