PDF(Pubmed)
Abstract：
Cancer Stem Cells (CSCs) are the main \"seeds\" for the initiation, growth, metastasis, and recurrence of tumors. According to many studies, several viral infections, including the human papillomaviruses, hepatitis B virus, Epstein-Barr virus, and hepatitis C virus, promote the aggressiveness of cancer by encouraging the development of CSC features. Therefore, a better method for the targeted elimination of CSCs and knowledge of their regulatory mechanisms in human carcinogenesis may lead to the development of a future tool for the management and treatment of cancer. Oncolytic viruses (OVs), which include the herpes virus, adenovirus, vaccinia, and reovirus, are also a new class of cancer therapeutics that have favorable properties such as selective replication in tumor cells, delivery of numerous eukaryotic transgene payloads, induction of immunogenic cell death and promotion of antitumor immunity, as well as a tolerable safety profile that essentially differs from that of other cancer therapeutics. The effects of viral infection on the development of CSCs and the suppression of CSCs by OV therapy were examined in this paper. The purpose of this review is to investigate the dual role of viruses in CSCs (oncolytic virotherapy and viral oncogenes).
摘要：
癌症干细胞（CSC）是启动的主要“种子”，增长,转移,和肿瘤复发。根据许多研究,几种病毒感染，包括人乳头瘤病毒,乙型肝炎病毒，爱泼斯坦-巴尔病毒,和丙型肝炎病毒，通过鼓励CSC特征的发展来促进癌症的侵袭性。因此,靶向清除CSC的更好方法及其在人类癌变过程中调控机制的知识可能导致开发未来的癌症管理和治疗工具.溶瘤病毒(OVs),其中包括疱疹病毒，腺病毒，牛痘,和呼肠孤病毒，也是一类新的癌症疗法，具有良好的特性，如在肿瘤细胞中的选择性复制，传递许多真核转基因有效载荷，诱导免疫原性细胞死亡和促进抗肿瘤免疫，以及与其他癌症疗法本质上不同的可耐受安全性。本文研究了病毒感染对CSCs发育的影响以及OV治疗对CSCs的抑制作用。这篇综述的目的是研究病毒在CSC中的双重作用（溶瘤病毒疗法和病毒致癌基因）。
