未经评估:抗微生物药物在全世界挽救了数百万人的生命。然而,不当使用已成为全球关注的问题,导致抗菌素耐药性(AMR)的出现和传播。在这方面,药房专业人员在社区药品零售店(CDRO)的配药实践起着核心作用.因此,本研究旨在评估埃塞俄比亚东部地区药学专业人员在CDRO治疗儿童腹泻方面的知识和配药实践.
UNASSIGNED:2020年8月1日至9月30日,在埃塞俄比亚东部随机选择的100个CDRO中进行了一项基于社区的横断面研究。使用与模拟患者病例匹配的结构化问卷收集数据。采用描述性统计来总结变量。对Cohen的Kappa进行了分析,以测量基于问卷的方法和基于模拟患者的方法之间的一致程度。进行了二元逻辑回归分析,以确定与不适当的分配实践相关的因素。
UNASSIGNED:大多数参与者年龄为25-34岁(中位数:29岁)。其中男性比例很高(65%),并且有两年或两年以上的工作经验。大多数(61%)的专业人员了解AMR。2886分,在Cohen的Kappa评分者间协议量表上,745个分数达成一致,两种方法之间的总体百分比为26.0%。此外,对模拟患者病例的约67%的配药实践被发现不合适。在多变量分析中,零售商对AMR的认识不足与抗菌药物配药不当显著相关.
UNASSIGNED:相当比例的零售商对AMR的出现和传播了解不足。只有四分之一的基于问卷的知识回答与基于模拟患者的实际实践一致,这表明两种方法之间的一致性很弱,实践的不当程度很高。此外,零售商的知识不足与抗菌药物的分配不当显著相关.
UNASSIGNED: Antimicrobial agents have saved millions of lives worldwide. However, inappropriate use has become a global concern leading to the emergence and spread of antimicrobial resistance (AMR). In this regard, the dispensing practices of pharmacy professionals in the community drug retail outlets (CDROs) plays a central role. Therefore, this study was aimed to assess the knowledge and dispensing practices of pharmacy professionals in the management of childhood diarrhea in CDROs of Eastern Ethiopia.
UNASSIGNED: A community based cross-sectional study was conducted in 100 randomly selected CDROs in Eastern Ethiopia from 1 August to 30 September 2020. Data were collected with a structured questionnaire matched with a simulated patient
case. Descriptive statistics were employed to summarize variables. Cohen\'s Kappa was analyzed to measure the degree of agreement between questionnaire-based and simulated patient-based methods. Binary logistic regression analysis was conducted to determine factors associated with inappropriate dispensing practice.
UNASSIGNED: Majority of the participants were aged 25-34 years (median: 29 years). High proportion of them were male (65%) and had work experiences of two or more years. Majority (61%) of the professionals were knowledgeable about AMR. Out of 2886 scores, 745 scores were agreed on Cohen\'s Kappa interrater agreement scale with the overall percent agreement between the two methods being 26.0%. Besides, about 67% of dispensing practices to the simulated patient
case was found inappropriate. On the multivariate analysis, insufficient knowledge of retailers on AMR was significantly associated with the inappropriate dispensing of antimicrobial agents.
UNASSIGNED: A considerable proportion of retailers had insufficient knowledge regarding the emergence and spread of AMR. Only a quarter of their questionnaire-based knowledge response agreed with simulated-patient-based actual practice, indicating weak agreement between the two methods and high level of inappropriate practice. Besides, insufficient knowledge of retailers was significantly associated with their inappropriate dispensing of antimicrobials.