■肥胖和代谢综合征(MetS)对青少年的健康和幸福有直接和长期的影响。在青少年MetS的可用治疗方法中,行为干预措施,如增加体力活动(PA)是首选。这项研究旨在调查PA和坐着时间与MetS和一整套代谢健康参数的关系。
■来自巴西儿童代谢综合征研究(BRAMS-P)的数据,一项横断面多中心研究,使用448名巴西青少年(10y-19y)的便利样本进行,被使用。使用标准化问卷收集社会人口统计学和生活方式信息。根据国际PA问卷估计每日PA和坐着时间。人体测量参数,身体成分,血压是由训练有素的研究人员测量的。血脂,尿酸,肝酶,肌酐,糖化血红蛋白,葡萄糖,在空腹血液样本中测量胰岛素,并计算胰岛素抵抗的稳态模型评估。57名青少年的子样本接受了高血糖钳夹方案。
■坐位时间>8小时的青少年患代谢综合征的几率更高(OR(95CI)=2.11(1.02-4.38)),但不在那些被归类为活动的人中(OR(95CI)=0.98(0.42-2.26))。花更多时间坐着的青少年的BMI更高,腰围,矢状腹部直径,颈围,身体脂肪的百分比,血脂状况更糟。胰岛素敏感性指数与每天分钟内的中高PA呈中度正相关(rho=0.29;p=0.047)。
■坐着的时间与更差的代谢参数相关,必须限制其有利于青少年健康。常规PA与改善的胰岛素敏感性相关,不仅在肥胖或代谢紊乱的青少年中可能受到鼓励,而且在体重正常的青少年中也可能预防不良的代谢结果。
Obesity and metabolic syndrome (MetS) have immediate and long-term consequences on adolescent health and well-being. Among the available treatments for MetS in adolescents, behavioral interventions such as increasing physical activity (PA) are preferred. This
study aimed to investigate the association of PA and
sitting time with MetS and a complete set of metabolic health parameters.
Data from the Pediatric Brazilian Metabolic Syndrome
Study (BRAMS-P), a cross-sectional multicenter
study conducted using a convenience sample of 448 Brazilian adolescents (10y-19y), were used. Sociodemographic and lifestyle information were collected using a standardized questionnaire. Daily PA and
sitting time were estimated from the International PA Questionnaire. Anthropometric parameters, body composition, and blood pressure were measured by trained researchers. Blood lipids, uric acid, hepatic enzymes, creatinine, glycated hemoglobin, glucose, and insulin were measured in fasting blood samples, and the Homeostasis Model Assessment for Insulin Resistance was calculated. A subsample of 57 adolescents underwent the hyperglycemic clamp protocol.
The odds for metabolic syndrome were higher among adolescents who spent >8h sitting (OR (95%CI)=2.11 (1.02 - 4.38)), but not in those classified as active (OR (95%CI)=0.98 (0.42 - 2.26)). Adolescents who spent more time sitting had higher BMI, waist circumference, sagittal abdominal diameter, neck circumference, percentage of body fat, and worse blood lipid profile. The insulin sensitivity index was moderately and positively correlated with moderate-to-high PA in minutes per day (rho=0.29; p=0.047).
Time spent
sitting was associated with worse metabolic parameters and must be restricted in favor of adolescent health. Regular PA is associated with improved insulin sensitivity and may be encouraged not only in adolescents with obesity or metabolic disorders but also to prevent adverse metabolic outcomes in normal-weight adolescents.