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Abstract：
BACKGROUND: Sedentary behaviour at work is a major cause of atherosclerosis, particularly in tertiary workers. However, no studies have ever assessed the effect of active workstation on lipoprotein subfraction profile. This study aimed to evaluate the effect of 12-week portable pedal machines (PPMs) on lipoprotein subfraction profile among healthy sedentary workers.
METHODS: Healthy administrative workers were randomized into an intervention group using PPMs for 12 weeks or a control group using normal-desk. Lipoprotein subfractions were assessed using Lipoprint® electrophoresis. Main outcomes were explored using mixed models with sensitivity analyses (four models).
RESULTS: We included 40 participants (43.7 ± 8.6 years old, 100% women, BMI 23.8 ± 3.4 kg/m2; sedentary time at work 7.7 ± 1.8 h/day). Groups did not differ at baseline in any outcomes. 32 participants finished the trial. Changes in lipoprotein subfractions were especially marked for LDL profile. There was an interaction time x group for all parameters related to LDL and their subfractions: total LDL-cholesterol (p = 0.012), LDL particle size (p = 0.027), large LDL subfractions 1 and 2 (p = 0.001), and small dense LDL subfractions 3 to 7 (p = 0.046), using the crude model. The interaction reflects difference in the direction of changes between groups. The LDL particle size significantly increased in the intervention group (from 271.9 ± 2.5 at t0 to 272.8 ± 1.9 Ångström at t1, p = 0.037) while it did not change in the control group (272.5 ± 1.7 at t0 to 271.8 ± 1.5Å at t1, p = 0.52). All interactions were constantly significant whatever the models. Influencing variables were mainly stress at work that was associated with an increase in total LDL-cholesterol (coefficient 3.15, 95CI 0.20 to 6.11 mg/dl, p = 0.038), and BMI that was associated with Large-LDL, Large-HDL, IDL-C and triglycerides.
CONCLUSIONS: Lipoprotein profile was improved after a 12-week PPMs intervention at work in healthy administrative workers. Changes were mainly showed for LDL and LDL subfractions. Lipoprotein profile was worsened by stress at work, BMI and age.
BACKGROUND: NCT04153214.
METHODS: Healthy administrative workers were randomized into an intervention group using PPMs for 12 weeks or a control group using normal-desk. Lipoprotein subfractions were assessed using Lipoprint® electrophoresis. Main outcomes were explored using mixed models with sensitivity analyses (four models).
RESULTS: We included 40 participants (43.7 ± 8.6 years old, 100% women, BMI 23.8 ± 3.4 kg/m2; sedentary time at work 7.7 ± 1.8 h/day). Groups did not differ at baseline in any outcomes. 32 participants finished the trial. Changes in lipoprotein subfractions were especially marked for LDL profile. There was an interaction time x group for all parameters related to LDL and their subfractions: total LDL-cholesterol (p = 0.012), LDL particle size (p = 0.027), large LDL subfractions 1 and 2 (p = 0.001), and small dense LDL subfractions 3 to 7 (p = 0.046), using the crude model. The interaction reflects difference in the direction of changes between groups. The LDL particle size significantly increased in the intervention group (from 271.9 ± 2.5 at t0 to 272.8 ± 1.9 Ångström at t1, p = 0.037) while it did not change in the control group (272.5 ± 1.7 at t0 to 271.8 ± 1.5Å at t1, p = 0.52). All interactions were constantly significant whatever the models. Influencing variables were mainly stress at work that was associated with an increase in total LDL-cholesterol (coefficient 3.15, 95CI 0.20 to 6.11 mg/dl, p = 0.038), and BMI that was associated with Large-LDL, Large-HDL, IDL-C and triglycerides.
CONCLUSIONS: Lipoprotein profile was improved after a 12-week PPMs intervention at work in healthy administrative workers. Changes were mainly showed for LDL and LDL subfractions. Lipoprotein profile was worsened by stress at work, BMI and age.
BACKGROUND: NCT04153214.
摘要：
背景：工作中的久坐行为是动脉粥样硬化的主要原因，特别是在第三级工人中。然而,尚无研究评估活动工作站对脂蛋白亚组分谱的影响.这项研究旨在评估12周便携式脚踏机（PPMs）对健康久坐工人脂蛋白亚组分的影响。
方法：健康管理人员随机分为使用PPMs的干预组12周或使用普通桌子的对照组。使用Lipoprint®电泳评估脂蛋白亚组分。使用混合模型和敏感性分析(四个模型)探索主要结果。
结果：我们包括40名参与者（43.7±8.6岁，100%女性BMI23.8±3.4kg/m2；工作久坐时间7.7±1.8h/天）。各组在任何结果的基线没有差异。32名参与者完成了试验。脂蛋白亚组分的变化对于LDL谱尤其明显。与LDL及其亚组分相关的所有参数都有一个相互作用时间x组：总LDL-胆固醇（p=0.012），LDL颗粒大小（p=0.027），大LDL亚组分1和2（p=0.001），和小的致密LDL亚组分3至7（p=0.046），使用粗略的模型。相互作用反映了群体之间变化方向的差异。干预组的LDL粒径显着增加（从t0时的271.9±2.5增加到t1时的272.8±1.9µngström，p=0.037），而对照组则没有变化（t0时的272.5±1.7到t1时的271.8±1.5，p=0.52）。无论采用何种模型，所有的相互作用都是持续显著的。影响变量主要是与总LDL-胆固醇增加相关的工作压力（系数3.15,95CI0.20至6.11mg/dl，p=0.038),以及与大低密度脂蛋白相关的BMI，大型HDL,IDL-C和甘油三酯。
结论：在健康行政工作者的工作中进行12周的PPMs干预后，脂蛋白谱得到改善。主要显示LDL和LDL亚组分的变化。脂蛋白谱因工作压力而恶化，BMI和年龄。
背景：NCT04153214。
方法：健康管理人员随机分为使用PPMs的干预组12周或使用普通桌子的对照组。使用Lipoprint®电泳评估脂蛋白亚组分。使用混合模型和敏感性分析(四个模型)探索主要结果。
结果：我们包括40名参与者（43.7±8.6岁，100%女性BMI23.8±3.4kg/m2；工作久坐时间7.7±1.8h/天）。各组在任何结果的基线没有差异。32名参与者完成了试验。脂蛋白亚组分的变化对于LDL谱尤其明显。与LDL及其亚组分相关的所有参数都有一个相互作用时间x组：总LDL-胆固醇（p=0.012），LDL颗粒大小（p=0.027），大LDL亚组分1和2（p=0.001），和小的致密LDL亚组分3至7（p=0.046），使用粗略的模型。相互作用反映了群体之间变化方向的差异。干预组的LDL粒径显着增加（从t0时的271.9±2.5增加到t1时的272.8±1.9µngström，p=0.037），而对照组则没有变化（t0时的272.5±1.7到t1时的271.8±1.5，p=0.52）。无论采用何种模型，所有的相互作用都是持续显著的。影响变量主要是与总LDL-胆固醇增加相关的工作压力（系数3.15,95CI0.20至6.11mg/dl，p=0.038),以及与大低密度脂蛋白相关的BMI，大型HDL,IDL-C和甘油三酯。
结论：在健康行政工作者的工作中进行12周的PPMs干预后，脂蛋白谱得到改善。主要显示LDL和LDL亚组分的变化。脂蛋白谱因工作压力而恶化，BMI和年龄。
背景：NCT04153214。
