METHODS: Healthy administrative workers were randomized into an intervention group using PPMs for 12 weeks or a control group using normal-desk. Lipoprotein subfractions were assessed using Lipoprint® electrophoresis. Main outcomes were explored using mixed models with sensitivity analyses (four models).
RESULTS: We included 40 participants (43.7 ± 8.6 years old, 100% women, BMI 23.8 ± 3.4 kg/m2; sedentary time at work 7.7 ± 1.8 h/day). Groups did not differ at baseline in any outcomes. 32 participants finished the trial. Changes in lipoprotein subfractions were especially marked for LDL profile. There was an interaction time x group for all parameters related to LDL and their subfractions: total LDL-cholesterol (p = 0.012), LDL particle size (p = 0.027), large LDL subfractions 1 and 2 (p = 0.001), and small dense LDL subfractions 3 to 7 (p = 0.046), using the crude model. The interaction reflects difference in the direction of changes between groups. The LDL particle size significantly increased in the intervention group (from 271.9 ± 2.5 at t0 to 272.8 ± 1.9 Ångström at t1, p = 0.037) while it did not change in the control group (272.5 ± 1.7 at t0 to 271.8 ± 1.5Å at t1, p = 0.52). All interactions were constantly significant whatever the models. Influencing variables were mainly stress at work that was associated with an increase in total LDL-cholesterol (coefficient 3.15, 95CI 0.20 to 6.11 mg/dl, p = 0.038), and BMI that was associated with Large-LDL, Large-HDL, IDL-C and triglycerides.
CONCLUSIONS: Lipoprotein profile was improved after a 12-week PPMs intervention at work in healthy administrative workers. Changes were mainly showed for LDL and LDL subfractions. Lipoprotein profile was worsened by stress at work, BMI and age.
BACKGROUND: NCT04153214.
方法:健康管理人员随机分为使用PPMs的干预组12周或使用普通桌子的对照组。使用Lipoprint®电泳评估脂蛋白亚组分。使用混合模型和敏感性分析(四个模型)探索主要结果。
结果:我们包括40名参与者(43.7±8.6岁,100%女性BMI23.8±3.4kg/m2;工作久坐时间7.7±1.8h/天)。各组在任何结果的基线没有差异。32名参与者完成了试验。脂蛋白亚组分的变化对于LDL谱尤其明显。与LDL及其亚组分相关的所有参数都有一个相互作用时间x组:总LDL-胆固醇(p=0.012),LDL颗粒大小(p=0.027),大LDL亚组分1和2(p=0.001),和小的致密LDL亚组分3至7(p=0.046),使用粗略的模型。相互作用反映了群体之间变化方向的差异。干预组的LDL粒径显着增加(从t0时的271.9±2.5增加到t1时的272.8±1.9µngström,p=0.037),而对照组则没有变化(t0时的272.5±1.7到t1时的271.8±1.5,p=0.52)。无论采用何种模型,所有的相互作用都是持续显著的。影响变量主要是与总LDL-胆固醇增加相关的工作压力(系数3.15,95CI0.20至6.11mg/dl,p=0.038),以及与大低密度脂蛋白相关的BMI,大型HDL,IDL-C和甘油三酯。
结论:在健康行政工作者的工作中进行12周的PPMs干预后,脂蛋白谱得到改善。主要显示LDL和LDL亚组分的变化。脂蛋白谱因工作压力而恶化,BMI和年龄。
背景:NCT04153214。