目前,在欧洲,大约五分之一的工人受雇于夜班工作。轮班工作,包括夜间时间是必不可少的几个活动,尤其是医疗保健部门。重要的是,夜间工作可能与睡眠障碍或工作相关压力的发生有关,两者都有可能增加工作中出错和事故的风险。这项研究旨在检查神经行为改变的存在,这可能是轮班工作以及睡眠时间和昼夜节律同时失调的结果。护士(n=102)受雇于位于西西里岛东北部的大学医院,意大利,自愿参加了这项试点研究。在医疗监视期间,早上和晚上收集唾液样本,并对所有受试者进行了7份心理诊断问卷。一方面,我们评估了应激相关生物标志物(皮质醇和α-淀粉酶)和昼夜节律生物标志物(褪黑素)的唾液水平.另一方面,评估了几种神经行为特征,包括抑郁症,焦虑,工作相关,和睡眠问题。有趣的是,唾液早晨皮质醇与抑郁量表呈正相关,以及唾液早晨α-淀粉酶和工作能力量表之间的负相关关系,被观察到。基于这些结果,主观问卷结果和客观唾液生物标志物量化的整合可以帮助识别更容易发生神经行为改变的工作者.这种方法可能有助于改善针对敏感类别的预防策略,如护士轮班工作。
Currently, about one in five workers is employed in night shift work in Europe. Shift work including nighttime hours is essential in several activities, especially the healthcare sector. Importantly, night working may be associated with the occurrence of sleep disorders or work-related stress, both potentially augmenting the risk of errors and accidents at work. This
study aims to examine the presence of neurobehavioral alterations that can be a consequence of shift working and concurrent misalignment of the sleep times and circadian rhythms. Nurses (n = 102) employed at a University Hospital located in North-Eastern
Sicily, Italy, voluntarily participated in this pilot
study. During medical surveillance, morning and evening salivary samples were collected, and seven psychodiagnostics questionnaires were administered to all the subjects. On one hand, the salivary levels of stress-related biomarkers (cortisol and alpha-amylase) and a circadian biomarker (melatonin) were evaluated. On the other hand, several neurobehavioral features were assessed, including depression, anxiety, work-related, and sleep issues. Interestingly, a positive relationship between salivary morning cortisol and depression scale, as well as a negative relationship between salivary morning alpha-amylase and work ability scale, were observed. Based on these results, the integration of subjective questionnaire outcomes and objective salivary biomarker quantification can help to identify workers with increased susceptibility to developing neurobehavioral alterations. This approach may contribute to ameliorating preventive strategies towards sensitive categories, such as nurses working rotation shifts.