目的:评估盖拉尿道下裂的风险状况,位于西西里岛地区(意大利南部)的意大利国家优先污染地点(NPCS),与区域参考数据相比,新生儿居民尿道下裂明显过量,国家,和国际基础,直到2014年,由于石化厂的存在。
方法:通过比较Gela市的患病率与西西里岛的患病率来进行地理分析,在与Gela(ALG)接壤的领土内,以及米拉佐和普里奥洛的非政府组织。对2010-2020年期间进行了地理比较,通过比较两个子时期(2010-2014年和2015-2020年)来评估GelaNPCS内部的趋势。
方法:2010-2020年期间,居住在Gela市的1岁以下尿道下裂儿童。
方法:使用粗比值比(OR)和相应的95%置信区间(95CI)来比较在Gela中观察到的患病率和在比较区域中检测到的患病率。
结果:2010-2020年Gelavs西西里岛突出显示了尿道下裂的额外风险(OR4.45;95CI3.45-5.75),与ALG(OR4.29;95CI3.02-6.10),和米拉佐的NPCSs(OR2.32;95CI1.32-4.07)和Priolo(OR2.37;95CI1.55-3.62)。Gela的间期比较没有显示2010-2014年和2015-2020年之间的重要差异(OR1.37;95CI0.83-2.24),患病率分别为98.9和72.4/10,000。
结论:2015-2020年尿道下裂的患病率仍然很高,虽然与2010-2014年相比有所下降。Gela的数据,尽管炼油厂在2014年后关闭,但这表明复杂的情况下,多种风险因素可能会发挥作用。
OBJECTIVE: to evaluate the risk profile of hypospadias in Gela, an Italian National Priority Contaminated Site (NPCS) located in
Sicily Region (Southern Italy), characterized by a significant excess of hypospadias in newborn residents compared to data from reference on regional, national, and international basis and, until 2014, by the presence of a petrochemical plant.
METHODS: geographical analyses were conducted by comparing the prevalence of the Gela municipality to prevalence found in
Sicily, in a territorial area bordering Gela (ALG), and in the NPCSs of Milazzo and Priolo. The geographical comparisons were conducted for the period 2010-2020, the trend within the Gela NPCS was evaluated by comparing two subperiods (2010-2014 and 2015-2020).
METHODS: children up to 1 year of age with hypospadias resident in the municipality of Gela in the period 2010-2020.
METHODS: crude odds ratios (OR) and respective 95% confidence intervals (95%CI) were used to compare the prevalence observed in Gela and that detected in the comparison areas.
RESULTS: excess risk for hypospadias was highlighted in 2010-2020 in Gela vs
Sicily (OR 4.45; 95%CI 3.45-5.75), vs ALG (OR 4.29; 95%CI 3.02-6.10), and vs the NPCSs of Milazzo (OR 2.32; 95%CI 1.32-4.07) and Priolo (OR 2.37; 95%CI 1.55-3.62). The between-period comparisons in Gela did not show an important difference between 2010-2014 and 2015-2020 (OR 1.37; 95%CI 0.83-2.24), with a prevalence of 98.9 and 72.4 per 10,000, respectively.
CONCLUSIONS: the prevalence of hypospadias in 2015-2020 remains very high, although decreasing when compared to 2010-2014 period. The Gela data, despite the refinery being closed after 2014, suggest a complex situation in which multiple risk factors may play a role.