PDF(Pubmed)
Abstract：
BACKGROUND: Influenza represents a serious public health threat, especially for the management of severe cases and complications of the disease, requiring the implementation of control measures. We aimed to assess the acceptance and impact of qLAIV vaccination among a representative sample of family paediatricians (FPs) operating in Palermo Local Health Authority (LHA). To this end we evaluated vaccination coverage rates, comparing it with that observed in Sicilian context, while actively monitoring possible adverse reactions and their severity.
METHODS: An observational descriptive non-controlled study was conducted in two phases, from September 2022 to June 2023. The first phase involved a formative and educational intervention with a pre-intervention questionnaire to assess the knowledge and attitudes of FPs on paediatric influenza vaccination. The second phase consisted of an active surveillance on qLAIV safety and acceptance among the paediatric population assisted by the participating FPs, from October 2022 to April 2023. Frequencies, chi-squared tests, and comparisons statistics were performed using Stata/MP 14.1.
RESULTS: The overall coverage rate among the paediatric population involved in the intervention was 13.2%, with an I.M./qLAIV ratio of vaccine administered of 1/4.25. This coverage rate was significantly higher (p-value <0.001) when compared to the average values reported in the population under the Palermo Local Health Authority (LHA) (6.7%) and in the entire Sicily (5.9%). Adverse events in the qLAIV group were mild, with only 3.3% experiencing them, primarily presenting as a feverish rise (3.2%). No severe adverse reaction was reported.
CONCLUSIONS: The educational intervention significantly raised paediatric influenza vaccination rates among the participating FPs, and in general improved influenza vaccination coverage rates in the Palermo\'s LHU. Minimal, non-serious adverse events underscored the vaccine\'s safety. Training sessions ensured paediatricians stayed informed, enabling them to provide comprehensive information to parents for secure and informed vaccination decisions in their practices.
METHODS: An observational descriptive non-controlled study was conducted in two phases, from September 2022 to June 2023. The first phase involved a formative and educational intervention with a pre-intervention questionnaire to assess the knowledge and attitudes of FPs on paediatric influenza vaccination. The second phase consisted of an active surveillance on qLAIV safety and acceptance among the paediatric population assisted by the participating FPs, from October 2022 to April 2023. Frequencies, chi-squared tests, and comparisons statistics were performed using Stata/MP 14.1.
RESULTS: The overall coverage rate among the paediatric population involved in the intervention was 13.2%, with an I.M./qLAIV ratio of vaccine administered of 1/4.25. This coverage rate was significantly higher (p-value <0.001) when compared to the average values reported in the population under the Palermo Local Health Authority (LHA) (6.7%) and in the entire Sicily (5.9%). Adverse events in the qLAIV group were mild, with only 3.3% experiencing them, primarily presenting as a feverish rise (3.2%). No severe adverse reaction was reported.
CONCLUSIONS: The educational intervention significantly raised paediatric influenza vaccination rates among the participating FPs, and in general improved influenza vaccination coverage rates in the Palermo\'s LHU. Minimal, non-serious adverse events underscored the vaccine\'s safety. Training sessions ensured paediatricians stayed informed, enabling them to provide comprehensive information to parents for secure and informed vaccination decisions in their practices.
摘要：
背景：流感是一种严重的公共卫生威胁，特别是对于严重病例和疾病并发症的管理，要求实施控制措施。我们旨在评估在巴勒莫地方卫生局（LHA）运营的家庭儿科医生（FPs）代表性样本中qLAIV疫苗接种的接受度和影响。为此，我们评估了疫苗接种率，将其与西西里背景下观察到的进行比较，同时积极监测可能的不良反应及其严重程度。
方法：一项观察性描述性非对照研究分两个阶段进行，从2022年9月到2023年6月。第一阶段包括形成性和教育性干预，并提供干预前问卷，以评估FPs对小儿流感疫苗接种的知识和态度。第二阶段包括积极监测qLAIV安全性和在参与的FP协助下的儿科人群的接受度，从2022年10月到2023年4月。频率,卡方检验,使用Stata/MP14.1进行比较统计。
结果：参与干预的儿科人群的总体覆盖率为13.2%，施用的疫苗的I.M./qLAIV比率为1/4.25。与巴勒莫地方卫生局（LHA）（6.7％）和整个西西里岛（5.9％）的人口报告的平均值相比，该覆盖率明显更高（p值<0.001）。qLAIV组的不良事件为轻度，只有3.3%的人经历过，主要表现为发烧上升(3.2%)。无严重不良反应报告。
结论：教育干预显著提高了参与项目的儿童流感疫苗接种率，总体上提高了巴勒莫LHU的流感疫苗接种率。最小,非严重不良事件强调了疫苗的安全性。培训课程确保儿科医生保持知情，使他们能够向父母提供全面的信息，以便在他们的实践中做出安全和明智的疫苗接种决定。
方法：一项观察性描述性非对照研究分两个阶段进行，从2022年9月到2023年6月。第一阶段包括形成性和教育性干预，并提供干预前问卷，以评估FPs对小儿流感疫苗接种的知识和态度。第二阶段包括积极监测qLAIV安全性和在参与的FP协助下的儿科人群的接受度，从2022年10月到2023年4月。频率,卡方检验,使用Stata/MP14.1进行比较统计。
结果：参与干预的儿科人群的总体覆盖率为13.2%，施用的疫苗的I.M./qLAIV比率为1/4.25。与巴勒莫地方卫生局（LHA）（6.7％）和整个西西里岛（5.9％）的人口报告的平均值相比，该覆盖率明显更高（p值<0.001）。qLAIV组的不良事件为轻度，只有3.3%的人经历过，主要表现为发烧上升(3.2%)。无严重不良反应报告。
结论：教育干预显著提高了参与项目的儿童流感疫苗接种率，总体上提高了巴勒莫LHU的流感疫苗接种率。最小,非严重不良事件强调了疫苗的安全性。培训课程确保儿科医生保持知情，使他们能够向父母提供全面的信息，以便在他们的实践中做出安全和明智的疫苗接种决定。
