Abstract：
The health of humans, animals and the environment is interconnected. Adopting a One Health approach means intervening promptly to prevent the main diseases that affect animal health to guarantee the safety of livestock production. Exposure to toxic trace elements in sheep can lead to increased accumulation in different biological substrate, developing both acute and chronic diseases in humans and livestock. The aim of this study was to evaluate the bioaccumulation of arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) in Sicilian Barbaresca sheep using the following biological substrates: milk, blood and fleece. An inductively coupled plasma mass spectrometer (ICP-MS) was used for As, Cd and Pb, and a direct mercury analyser (DMA-80) was used for Hg determination. In addition, the role of the haematological parameters as possible indicators of different biodistribution was evaluated. A statistically significant value was observed from our analysed metals in the substrates: arsenic (p < 0.001), cadmium (p < 0.01), lead (p < 0.001) and mercury (p < 0.0001). The correlation analysis showed a relationship between milk and blood for arsenic (p < 0.0001) and lead (p < 0.0001), and no correlation for the metals was observed between milk/blood and the haematological parameters analysed for the low concentration observed in the present study comforting the final consumer.
摘要：
人类的健康，动物和环境是相互联系的。采取“一个健康”的方法意味着及时干预以预防影响动物健康的主要疾病，以确保畜牧业生产安全。绵羊暴露于有毒微量元素会导致在不同生物基质中的积累增加，在人类和牲畜中发展急性和慢性疾病。这项研究的目的是评估砷（As）的生物积累，镉(Cd),使用以下生物底物在西西里巴黎斯卡绵羊中的铅（Pb）和汞（Hg）：牛奶，血和羊毛.电感耦合等离子体质谱仪(ICP-MS)用于As,Cd和Pb,直接汞分析仪（DMA-80）用于汞的测定。此外,评估了血液学参数作为不同生物分布的可能指标的作用.从我们分析的基材中的金属中观察到统计学上的显着值：砷（p<0.001），镉（p<0.01），铅(p<0.001)和汞(p<0.0001)。相关性分析显示牛奶和血液中砷(p<0.0001)和铅(p<0.0001)的关系,并且在本研究中观察到的低浓度安慰最终消费者的血液/血液与分析的血液学参数之间没有观察到金属的相关性。
