背景:关于肌肉减少症与慢性肺病(CLD)的相关性的数据导致了不确定的结果。这项研究的主要目的是调查中国中老年人肌少症与CLD之间的关系。
方法:研究样本包括从2015年中国健康与退休纵向研究(CHARLS)数据中选择的基线无CLD的11,077人,随访至2018年。使用亚洲肌肉减少症工作组(AWGS2019)在2019年设定的标准确定了肌肉减少症。个人被归类为无肌肉减少症,可能的肌肉减少症,和肌少症组。这项研究的结果被认为是偶然的CLD,其中包括慢性支气管炎,肺气肿,肺心病,和哮喘。还通过使用加权Cox比例风险回归模型来检查肌肉减少症与CLD风险之间的关联。
结果:在3.6年的随访期内,共有356名(3.20%)参与者发生了CLD。非肌肉减少症中CLD的累积发生率,可能的肌肉减少症,肌少症组为2.80%(230/8222),4.37%(55/1260),和4.45%(71/1595),分别。与无肌少症组的个体相比,具有可能的肌少症{风险比[HR][95%置信区间(CI)]:1.48[1.04-2.09]}和肌少症[HR(95%CI):1.68(1.12-2.51)]的个体表现出发生CLD的相当高的风险。此外,诊断为肌肉减少症的个体,根据欧洲老年人肌肉减少症工作组(EWGSOP)2018制定的标准,与非肌肉减少症组相比,发生CLD的风险相当高.
结论:这项涉及中国成年人的研究表明,可能的肌肉减少症和肌肉减少症,发生CLD的风险升高,从而强调监测这一人群呼吸健康的重要性。
结论:问题:在亚洲中老年人中,肌肉质量和肌肉减少症是否与慢性肺病(CLD)的发展有关。
结果:这项纵向研究涵盖了来自中国健康与退休纵向研究(CHARLS)数据的11,077名年龄≥45岁的成年人,并进行了3.6年的随访,结果显示基线时肌肉减少症[HR(95%CI):1.68(1.12-2.51)]与CLD发生率之间存在正相关。意义:研究结果表明,可能的肌少症和肌少症与CLD的发展有关。因此,关于CLD的一级预防策略,可能患有少肌症和少肌症的中老年人可被认为是脆弱的.
Data regarding the association of sarcopenia with chronic lung disease (CLD) has led to inconclusive results. The main goal of this research was to investigate the association between sarcopenia and CLD in middle-aged and elderly individuals in China.
The
study sample consisted of 11,077 individuals without CLD at baseline chosen from the China Health and Retirement Longitudinal
Study (CHARLS) data from 2015, followed up until 2018. Sarcopenia was identified utilizing the criteria set by the Asian Working Group on Sarcopenia (AWGS 2019) in 2019. Individuals were categorized into no-sarcopenia, possible-sarcopenia, and sarcopenia groups. The outcome of the
study was considered to be incident CLD, which included chronic bronchitis, emphysema, pulmonary heart disease, and asthma. The association between sarcopenia and the risk of CLD was also examined by employing weighted Cox proportional hazard regression models.
A total of 356 (3.20 %) participants developed CLD during the 3.6-year follow-up period. The cumulative incidence of CLD in the no-sarcopenia, possible-sarcopenia, and sarcopenia groups was 2.80 % (230/8222), 4.37 % (55/1260), and 4.45 % (71/1595), respectively. Individuals with possible sarcopenia {hazard ratio [HR] [95 % confidence interval (CI)]: 1.48 [1.04-2.09]} and sarcopenia [HR (95 % CI): 1.68 (1.12-2.51)] demonstrated a considerably high risk of developing CLD compared to individuals in the no-sarcopenia group. Moreover, individuals diagnosed with sarcopenia, as per the criteria established by the European Working Group on Sarcopenia in Older People (EWGSOP) 2018, were at considerably high risk for developing CLD compared to those in the no-sarcopenia group.
This research involving adult Chinese individuals demonstrated a significant association between, possible sarcopenia and sarcopenia with an elevated risk of incident CLD, thereby emphasizing the importance of monitoring respiratory health in this population.
Question: Whether muscle mass and sarcopenia are associated with the development of chronic lung disease (CLD) in Asian middle-aged and elderly individuals.
This longitudinal
study encompassing 11,077 adults aged ≥45 years from the China Health and Retirement Longitudinal
Study (CHARLS) data with 3.6 years of follow-up revealed a positive association between sarcopenia at baseline and incidence of CLD. Meaning: The findings suggest that possible sarcopenia and sarcopenia are linked to the development of CLD. Consequently, middle-aged and elderly individuals with possible sarcopenia and sarcopenia can be considered vulnerable regarding the primary prevention strategies for CLD.