METHODS: Ambispective cohort study on the healthy adult population. Three exposure groups were considered: Group 1, high exposure; Group 2, moderate exposure; and Group 3, minor or no exposure. We carried out a descriptive analysis of symptoms during and after the eruption, as well as measure lung function after the eruption (through forced spirometry and diffusing capacity of carbon monoxide).
RESULTS: The analysis included 474 subjects: 54 in Group 1, 335 in Group 2, and 85 in Group 3. A significant increase in most symptoms was observed for subjects in the groups exposed during the eruption. After the eruption, this increase remained for some symptoms. There seems to be a dose-response relationship, such that the higher the exposure, the higher the odds ratio. A prebronchodilator FEV1/FVC ratio<70% was observed in 13.0% of subjects in Group 1, 8.6% of subjects in Group 2, and 7.1% of subjects in Group 3.
CONCLUSIONS: This study is the first to report a dose-response relationship between exposure to volcanic eruptions and the presence of symptoms in adults. Furthermore, there is a tendency toward obstructive impairment in individuals with higher exposure.
方法:对健康成年人群进行综合队列研究。考虑了三个暴露组:第1组,高暴露;第2组,中度暴露;第3组,轻度或无暴露。我们对喷发期间和之后的症状进行了描述性分析,以及测量喷发后的肺功能(通过强制肺活量和一氧化碳的扩散能力)。
结果:分析包括474名受试者:第1组54名,第2组335名,第3组85名。在喷发期间暴露的组中观察到大多数症状的显着增加。喷发之后,这种增加仍然存在一些症状。似乎有剂量反应关系,这样曝光越高,赔率比越高。在组1中13.0%的受试者、组2中8.6%的受试者和组3中7.1%的受试者中观察到<70%的支气管扩张剂前FEV1/FVC比率。
结论:这项研究首次报道了接触火山喷发与成人症状之间的剂量反应关系。此外,暴露量较高的个体有阻塞性损害的趋势。