Abstract：
BACKGROUND: Exposure to gases and particulate matter released during volcanic eruptions can prove harmful to population health. This paper reports the preliminary results of the ASHES study, aimed at ascertaining the respiratory health effects of the 2021 volcanic eruption in La Palma Island (Spain) on the adult population without previous respiratory disease.
METHODS: Ambispective cohort study on the healthy adult population. Three exposure groups were considered: Group 1, high exposure; Group 2, moderate exposure; and Group 3, minor or no exposure. We carried out a descriptive analysis of symptoms during and after the eruption, as well as measure lung function after the eruption (through forced spirometry and diffusing capacity of carbon monoxide).
RESULTS: The analysis included 474 subjects: 54 in Group 1, 335 in Group 2, and 85 in Group 3. A significant increase in most symptoms was observed for subjects in the groups exposed during the eruption. After the eruption, this increase remained for some symptoms. There seems to be a dose-response relationship, such that the higher the exposure, the higher the odds ratio. A prebronchodilator FEV1/FVC ratio<70% was observed in 13.0% of subjects in Group 1, 8.6% of subjects in Group 2, and 7.1% of subjects in Group 3.
CONCLUSIONS: This study is the first to report a dose-response relationship between exposure to volcanic eruptions and the presence of symptoms in adults. Furthermore, there is a tendency toward obstructive impairment in individuals with higher exposure.
METHODS: Ambispective cohort study on the healthy adult population. Three exposure groups were considered: Group 1, high exposure; Group 2, moderate exposure; and Group 3, minor or no exposure. We carried out a descriptive analysis of symptoms during and after the eruption, as well as measure lung function after the eruption (through forced spirometry and diffusing capacity of carbon monoxide).
RESULTS: The analysis included 474 subjects: 54 in Group 1, 335 in Group 2, and 85 in Group 3. A significant increase in most symptoms was observed for subjects in the groups exposed during the eruption. After the eruption, this increase remained for some symptoms. There seems to be a dose-response relationship, such that the higher the exposure, the higher the odds ratio. A prebronchodilator FEV1/FVC ratio<70% was observed in 13.0% of subjects in Group 1, 8.6% of subjects in Group 2, and 7.1% of subjects in Group 3.
CONCLUSIONS: This study is the first to report a dose-response relationship between exposure to volcanic eruptions and the presence of symptoms in adults. Furthermore, there is a tendency toward obstructive impairment in individuals with higher exposure.
摘要：
背景：接触火山喷发过程中释放的气体和颗粒物可能会对人群健康有害。本文报告了ASHES研究的初步结果，旨在确定2021年拉帕尔马岛（西班牙）火山喷发对没有先前呼吸道疾病的成年人群的呼吸道健康影响。
方法：对健康成年人群进行综合队列研究。考虑了三个暴露组：第1组，高暴露；第2组，中度暴露；第3组，轻度或无暴露。我们对喷发期间和之后的症状进行了描述性分析，以及测量喷发后的肺功能（通过强制肺活量和一氧化碳的扩散能力）。
结果：分析包括474名受试者：第1组54名，第2组335名，第3组85名。在喷发期间暴露的组中观察到大多数症状的显着增加。喷发之后,这种增加仍然存在一些症状。似乎有剂量反应关系，这样曝光越高，赔率比越高。在组1中13.0%的受试者、组2中8.6%的受试者和组3中7.1%的受试者中观察到<70%的支气管扩张剂前FEV1/FVC比率。
结论：这项研究首次报道了接触火山喷发与成人症状之间的剂量反应关系。此外，暴露量较高的个体有阻塞性损害的趋势。
方法：对健康成年人群进行综合队列研究。考虑了三个暴露组：第1组，高暴露；第2组，中度暴露；第3组，轻度或无暴露。我们对喷发期间和之后的症状进行了描述性分析，以及测量喷发后的肺功能（通过强制肺活量和一氧化碳的扩散能力）。
结果：分析包括474名受试者：第1组54名，第2组335名，第3组85名。在喷发期间暴露的组中观察到大多数症状的显着增加。喷发之后,这种增加仍然存在一些症状。似乎有剂量反应关系，这样曝光越高，赔率比越高。在组1中13.0%的受试者、组2中8.6%的受试者和组3中7.1%的受试者中观察到<70%的支气管扩张剂前FEV1/FVC比率。
结论：这项研究首次报道了接触火山喷发与成人症状之间的剂量反应关系。此外，暴露量较高的个体有阻塞性损害的趋势。
