■肥胖是一种涉及不同代谢途径和脂肪组织细胞失调的病理状态,构成其他疾病发展的危险因素。减肥手术是最有效的治疗方法。对极端体重减轻情况下污染物行为的研究可以提供生物监测信息和工具来管理环境病因疾病。
■确定接受减肥手术的肥胖患者血清持久性和非持久性污染物的患病率,并分析社会人口统计学变量对这些变化的影响。
■利用GC-MS/MS和UHPLC-MS/MS测定了353种化合物的检出率和浓度,包括持久性有机污染物(POPs),杀虫剂,制药,和杀鼠剂,在接受减肥手术前后的59名肥胖患者的血清样本中。
■p,p\'-DDE,HCB,β-HCH,萘,由于手术引起的体重减轻,菲和PCB同源物138、153和180显着增加。血清P,p\'-DDE,PCB-138,PCB-153和PCB-180在手术后也增加。萘水平之间的相关性,减肥,发现总脂和术后时间的变化。此外,观察到PCB-138浓度与体重减轻之间的相关性,以及菲水平和总脂质减少之间。其他污染物组没有观察到统计学上的显著差异,量化方法中包括的药品和其他化学品。
■减肥手术后观察到POPs的增加。手术后POPs的血清浓度受肥胖相关变量的影响。尽管生物监测研究表明暴露趋势下降,快速的体重减轻导致循环POPs的增加。进一步研究脂肪组织之间的相互作用,POPs和周围器官是必需的。
UNASSIGNED: Obesity is a pathological state that involves the dysregulation of different metabolic pathways and adipose tissue cells, constituting a risk factor for the development of other diseases. Bariatric surgery is the most effective treatment. The
study of the behavior of pollutants in situations of extreme weight loss can provide biomonitoring information and tools to manage diseases of environmental etiology.
UNASSIGNED: To determine the prevalence of serum persistent and non-persistent pollutants in obese patients subjected to bariatric surgery and analyze the impact of sociodemographic variables on these changes.
UNASSIGNED: GC-MS/MS and UHPLC-MS/MS were utilized to determine the detection rates and concentrations of 353 compounds, including persistent organic pollutants (POPs), pesticides, pharmaceuticals, and rodenticide, in serum samples of 59 obese patients before and after undergoing bariatric surgery.
UNASSIGNED: Detection rates of p,p\'-DDE, HCB, β-HCH, naphthalene, phenanthrene and PCB congeners 138, 153 and 180 significantly increased due to surgery-induced weight loss. Serum levels of p,p\'-DDE, PCB-138, PCB-153 and PCB-180 also increased after surgery. Correlations between naphthalene levels, weight loss, variation of total lipids and time after surgery were found. Additionally, correlations were observed between concentrations of PCB-138 and weight loss, and between phenanthrene levels and reduction of total lipids. No statistically significant differences were observed for other groups of contaminants, pharmaceuticals and other chemicals included in the quantification methods.
UNASSIGNED: Increment of POPs was observed after bariatric surgery. Serum concentrations of POPs after surgery were influenced by adiposity-related variables. Although biomonitoring studies show a decreasing tendency of exposure, rapid weight loss leads to an increase of circulating POPs. Further research on the interplay between adipose tissue, POPs and peripheral organs is required.