PDF(Pubmed)
Abstract：
UNASSIGNED: The aim was to evaluate the possible association between some endocrine disruptive chemicals and thyroid cancer (TC) in an Italian case-control cohort.
UNASSIGNED: We enrolled 112 TC patients and 112 sex- and age-matched controls without known thyroid diseases. Per- and poly-fluoroalkyl substances (PFAS), poly-chlorinated biphenyls (PCBs), and dichlorodiphenyltrichloroethane (4,4\'-DDT and 4,4\'-DDE) were measured in the serum by liquid or gas chromatography-mass spectrometry. Unconditional logistic regression, Bayesan kernel machine regression and weighted quantile sum models were used to estimate the association between TC and pollutants\' levels, considered individually or as mixture. BRAFV600E mutation was assessed by standard methods.
UNASSIGNED: The detection of perfluorodecanoic acid (PFDA) was positively correlated to TC (OR = 2.03, 95% CI: 1.10-3.75, P = 0.02), while a negative association was found with perfluorohexanesulfonic acid (PFHxS) levels (OR = 0.63, 95% CI: 0.41-0.98, P = 0.04). Moreover, perfluorononanoic acid (PFNA) was positively associated with the presence of thyroiditis, while PFHxS and perfluorooctane sulfonic acid (PFOS) with higher levels of presurgical thyroid-stimulating hormone (TSH). PFHxS, PFOS, PFNA, and PFDA were correlated with less aggressive TC, while poly-chlorinated biphenyls (PCB-105 and PCB-118) with larger and more aggressive tumors. Statistical models showed a negative association between pollutants\' mixture and TC. BRAF V600E mutations were associated with PCB-153, PCB-138, and PCB-180.
UNASSIGNED: Our study suggests, for the first time in a case-control population, that exposure to some PFAS and PCBs associates with TC and some clinical and molecular features. On the contrary, an inverse correlation was found with both PFHxS and pollutants\' mixture, likely due to a potential reverse causality.
UNASSIGNED: We enrolled 112 TC patients and 112 sex- and age-matched controls without known thyroid diseases. Per- and poly-fluoroalkyl substances (PFAS), poly-chlorinated biphenyls (PCBs), and dichlorodiphenyltrichloroethane (4,4\'-DDT and 4,4\'-DDE) were measured in the serum by liquid or gas chromatography-mass spectrometry. Unconditional logistic regression, Bayesan kernel machine regression and weighted quantile sum models were used to estimate the association between TC and pollutants\' levels, considered individually or as mixture. BRAFV600E mutation was assessed by standard methods.
UNASSIGNED: The detection of perfluorodecanoic acid (PFDA) was positively correlated to TC (OR = 2.03, 95% CI: 1.10-3.75, P = 0.02), while a negative association was found with perfluorohexanesulfonic acid (PFHxS) levels (OR = 0.63, 95% CI: 0.41-0.98, P = 0.04). Moreover, perfluorononanoic acid (PFNA) was positively associated with the presence of thyroiditis, while PFHxS and perfluorooctane sulfonic acid (PFOS) with higher levels of presurgical thyroid-stimulating hormone (TSH). PFHxS, PFOS, PFNA, and PFDA were correlated with less aggressive TC, while poly-chlorinated biphenyls (PCB-105 and PCB-118) with larger and more aggressive tumors. Statistical models showed a negative association between pollutants\' mixture and TC. BRAF V600E mutations were associated with PCB-153, PCB-138, and PCB-180.
UNASSIGNED: Our study suggests, for the first time in a case-control population, that exposure to some PFAS and PCBs associates with TC and some clinical and molecular features. On the contrary, an inverse correlation was found with both PFHxS and pollutants\' mixture, likely due to a potential reverse causality.
摘要：
目的：评估意大利病例对照队列中某些内分泌破坏性化学物质与甲状腺癌（TC）之间的可能关联。
方法：我们招募了112名TC患者和112名性别和年龄相匹配的对照组，没有已知的甲状腺疾病。全氟烷基和多氟烷基物质（PFAS），多氯联苯（PCB），和二氯二苯基三氯乙烷(4,4'-DDT，和4,4'-DDE）通过液相或气相色谱-质谱法在血清中测量。非条件Logistic回归，贝叶斯核机器回归和加权分位数和模型用于估计TC和污染物水平之间的关联，单独或混合考虑。通过标准方法评估BRAFV600E突变。
结果：全氟癸酸（PFDA）的检测与TC呈正相关（OR=2.03，95％CI1.10-3.75，p=0.02），而与全氟己磺酸（PFHxS）水平呈负相关（OR=0.63，95％CI0.41-0.98，p=0.04）。此外，全氟壬酸（PFNA）与甲状腺炎的存在呈正相关，而PFHxS和全氟辛烷磺酸（PFOS）的术前促甲状腺激素（TSH）水平较高。PFHxS,全氟辛烷磺酸,PFNA和PFDA与较低侵袭性TC相关，而多氯联苯（PCB-105和PCB-118）具有更大和更具侵袭性的肿瘤。统计模型显示，污染物混合物与TC之间呈负相关。BRAFV600E突变与PCB-153、PCB-138和PCB-180相关。
结论：我们的研究表明，第一次在病例对照人群中，暴露于某些PFAS和PCBs与TC以及某些临床和分子特征相关。相反,发现PFHxS和污染物混合物呈负相关，可能是由于潜在的反向因果关系。
方法：我们招募了112名TC患者和112名性别和年龄相匹配的对照组，没有已知的甲状腺疾病。全氟烷基和多氟烷基物质（PFAS），多氯联苯（PCB），和二氯二苯基三氯乙烷(4,4'-DDT，和4,4'-DDE）通过液相或气相色谱-质谱法在血清中测量。非条件Logistic回归，贝叶斯核机器回归和加权分位数和模型用于估计TC和污染物水平之间的关联，单独或混合考虑。通过标准方法评估BRAFV600E突变。
结果：全氟癸酸（PFDA）的检测与TC呈正相关（OR=2.03，95％CI1.10-3.75，p=0.02），而与全氟己磺酸（PFHxS）水平呈负相关（OR=0.63，95％CI0.41-0.98，p=0.04）。此外，全氟壬酸（PFNA）与甲状腺炎的存在呈正相关，而PFHxS和全氟辛烷磺酸（PFOS）的术前促甲状腺激素（TSH）水平较高。PFHxS,全氟辛烷磺酸,PFNA和PFDA与较低侵袭性TC相关，而多氯联苯（PCB-105和PCB-118）具有更大和更具侵袭性的肿瘤。统计模型显示，污染物混合物与TC之间呈负相关。BRAFV600E突变与PCB-153、PCB-138和PCB-180相关。
结论：我们的研究表明，第一次在病例对照人群中，暴露于某些PFAS和PCBs与TC以及某些临床和分子特征相关。相反,发现PFHxS和污染物混合物呈负相关，可能是由于潜在的反向因果关系。
