Abstract：
Persistent organic pollutants may negatively impact cognition; however, associations between persistent organic pollutants and changes in cognition among United States Hispanic/Latino adults have not been investigated. Herein, we examined the associations between 33 persistent organic pollutants and cognitive changes among 1837 Hispanic/Latino adults. At baseline (2008-2011; Visit 1), participants provided biospecimens in which we measured levels of 5 persistent pesticides or pesticide metabolites, 4 polybrominated diphenyl ethers and 2,2\',4,4\',5,5\'-hexabromobiphenyl, and 24 polychlorinated biphenyls. At Visit 1 and again at Visit 2 (2015-2018), a battery of neurocognitive tests was administered which included the Brief-Spanish English Verbal Learning Test, Word Fluency Test, and Digit Symbol Substitution Test. To estimate the adjusted associations between changes in cognition and each POP, we used linear regression for survey data. Each doubling in plasma levels of polychlorinated biphenyls 146, 178, 194, 199/206, and 209 was associated with steeper declines in global cognition (βs range:-0.053 to -0.061) with stronger associations for the Brief-Spanish English Verbal Learning Test. Persistent organic pollutants, in particular polychlorinated biphenyls, were associated with declines in cognition over 7 years and may be a concern for Hispanic/Latino adults.
摘要：
持久性有机污染物可能会对认知产生负面影响；然而，持久性有机污染物与美国西班牙裔/拉丁裔成年人认知变化之间的关联尚未得到研究.在这里，我们研究了1837名西班牙裔/拉丁裔成年人中33种持久性有机污染物与认知改变之间的关联.在基线(2008-2011年；访问1)，参与者提供了生物样本，其中我们测量了5种持久性农药或农药代谢物的水平，4个多溴二苯醚和2,2'，4,4\'，5,5'-六溴代二苯，和24种多氯联苯。在访问1和访问2再次（2015-2018），进行了一系列神经认知测试，其中包括简短的西班牙语英语言语学习测试，单词流利度测试,和数字符号替换测试。为了估计认知变化与每种POP之间的调整后关联，我们对调查数据使用线性回归。多氯联苯146、178、194、199/206和209的血浆水平每增加一倍，都与全球认知的急剧下降（βs范围：-0.053至-0.061）相关，而简短西班牙语英语语言学习测试的相关性更强。持久性有机污染物，特别是多氯联苯，与超过7年的认知能力下降有关，可能是西班牙裔/拉丁裔成年人的担忧。
