目的:反式脂肪酸(TFA)与多种疾病的风险增加有关,如心血管疾病(CVD),糖尿病,和癌症。然而,血浆TFA与偏头痛之间的关系鲜为人知。当前的研究旨在确定美国成年人中血浆TFA与偏头痛之间的关联。
方法:美国国家健康和营养调查(NHANES)的参与者包括在1999-2000年期间。四种主要TFA的血浆浓度,包括棕榈酸(C16:1n-7t),反油酸(C18:1n-9t),疫苗酸(C18:1n-7t),和亚油酸(C18:2n-6t,9t)经气相色谱/质谱(GC/MS)测定。偏头痛的存在通过自我报告问卷确定。采用加权多变量logistic回归和有限三次样条(RCS)回归评价血浆TFA与偏头痛的关系。此外,采用交互术语的分层分析和检验,按性别评估效果修改,年龄,种族/民族,家庭收入,BMI。
结果:共纳入1534名参与者。严重头痛或偏头痛的总体加权患病率为21.2%。在调整所有潜在协变量后,血浆反油酸和亚油酸水平与偏头痛呈正相关。调整后的OR值分别为1.18(95CI:1.08-1.29,p=0.014,每增加10个单位)和1.24(95CI:1.07-1.44,p=0.024)。然后根据血浆TFA水平将纳入的参与者分为2分位数。与血浆反油酸和亚油酸水平较低的参与者(Q1组)相比,在模型2中校正所有协变量后,Q2组的偏头痛患病率较高.反油酸的调整OR值为2.43(95CI:1.14-5.18,p=0.037),亚油酸为2.18(95CI:1.14-4.20,p=0.036)。当分析按性别分层时,结果是稳健的,年龄,种族/民族,家庭收入,BMI,并且没有发现对关联的影响修饰。
结论:我们的结果表明,在美国成年人中,偏头痛患病率与血浆中的反油酸和亚油酸水平呈正相关。这些结果强调了循环TFA与偏头痛之间的联系。
OBJECTIVE: Trans-fatty acid (TFA) has been linked to an increased risk of a variety of diseases, such as cardiovascular disease (CVD), diabetes, and cancer. However, the relationship between plasma TFAs and migraine is little known. The current
study aimed to determine the association between plasma TFAs and migraine in a large cross-sectional
study among U.S. adults.
METHODS: The participants from the US National Health and Nutrition Examination Survey (NHANES) were included during the period 1999-2000. The plasma concentrations of four major TFAs, including palmitelaidic acid (C16:1n-7t), elaidic acid (C18:1n-9t), vaccenic acid (C18:1n-7t), and linolelaidic acid (C18:2n-6t, 9t) were measured by gas chromatography/mass spectrometry (GC/MS). The presence of migraine headache was determined by self-report questionnaire. Weighted multivariable logistic regressions and restricted cubic spline (RCS) regressions were explored to assess the relationship between plasma TFAs and migraine. Furthermore, stratified analysis and testing of interaction terms were used to evaluate the effect modification by sex, age, race/ethnicity, family income, and BMI.
RESULTS: A total of 1534 participants were included. The overall weighted prevalence of severe headache or migraine was 21.2 %. After adjusting for all potential covariates, plasma levels of elaidic acid and linolelaidic acid were positively associated with migraine. The adjusted OR values were 1.18 (95 %CI: 1.08-1.29, p=0.014, per 10 units increase) and 1.24 (95 %CI: 1.07-1.44, p=0.024). Then the included participants were divided into 2-quantiles by plasma TFA levels. Compared with participants with lower plasma levels of elaidic acid and linolelaidic acid (Q1 groups), those in the Q2 group had a higher prevalence of migraine when adjusted for all covariates in Model 2. The adjusted OR values were 2.43 (95 %CI: 1.14-5.18, p=0.037) for elaidic acid, and 2.18 (95 %CI: 1.14-4.20, p=0.036) for linolelaidic acid. Results were robust when analyses were stratified by sex, age, race/ethnicity, family income, and BMI, and no effect modification on the association was found.
CONCLUSIONS: Our results demonstrated a positive association between migraine prevalence and plasma levels of elaidic acid and linolelaidic acid in US adults. These results highlight the connection between circulating TFAs and migraine.