PDF(Pubmed)
Abstract：
As the most abundant fatty acid in plasma, oleic acid has been found to be associated with multiple neurological diseases; however, results from studies of the relationship between oleic acid and depression are inconsistent.
This cross-sectional study analyzed 4,459 adults from the National Health and Nutrition Examination Survey 2011-2014. The following covariates were adjusted in multivariable logistic regression models: age, sex, race/ethnicity, education level, marital status, body mass index, physical activity, smoking status, alcohol status, metabolic syndrome, omega-3 polyunsaturated fatty acids, and total cholesterol.
Serum oleic acid levels were positively associated with depression. After adjusting for all covariates, for every 1 mmol/L increase in oleic acid levels, the prevalence of depression increased by 40% (unadjusted OR: 1.35, 95%CI: 1.16-1.57; adjusted OR: 1.40, 95% CI: 1.03-1.90).
Our study suggests that oleic acid may play a role in depression. Further research is needed to investigate the potential benefits of changing oleic acid levels for the treatment and prevention of depression.
This cross-sectional study analyzed 4,459 adults from the National Health and Nutrition Examination Survey 2011-2014. The following covariates were adjusted in multivariable logistic regression models: age, sex, race/ethnicity, education level, marital status, body mass index, physical activity, smoking status, alcohol status, metabolic syndrome, omega-3 polyunsaturated fatty acids, and total cholesterol.
Serum oleic acid levels were positively associated with depression. After adjusting for all covariates, for every 1 mmol/L increase in oleic acid levels, the prevalence of depression increased by 40% (unadjusted OR: 1.35, 95%CI: 1.16-1.57; adjusted OR: 1.40, 95% CI: 1.03-1.90).
Our study suggests that oleic acid may play a role in depression. Further research is needed to investigate the potential benefits of changing oleic acid levels for the treatment and prevention of depression.
摘要：
背景：作为血浆中最丰富的脂肪酸，已发现油酸与多种神经系统疾病有关；然而，油酸与抑郁症关系的研究结果不一致。
方法：这项横断面研究分析了2011-2014年国家健康和营养检查调查的4,459名成年人。在多变量逻辑回归模型中调整了以下协变量：年龄，性别,种族/民族,教育水平,婚姻状况,身体质量指数,身体活动,吸烟状况,酒精状态,代谢综合征,omega-3多不饱和脂肪酸，和总胆固醇。
结果：血清油酸水平与抑郁症呈正相关。在调整所有协变量后，油酸水平每增加1mmol/L，抑郁症患病率增加了40%(未调整OR:1.35,95CI:1.16-1.57;调整OR:1.40,95%CI:1.03-1.90).
结论：我们的研究表明油酸可能在抑郁症中起作用。需要进一步的研究来研究改变油酸水平对治疗和预防抑郁症的潜在益处。
方法：这项横断面研究分析了2011-2014年国家健康和营养检查调查的4,459名成年人。在多变量逻辑回归模型中调整了以下协变量：年龄，性别,种族/民族,教育水平,婚姻状况,身体质量指数,身体活动,吸烟状况,酒精状态,代谢综合征,omega-3多不饱和脂肪酸，和总胆固醇。
结果：血清油酸水平与抑郁症呈正相关。在调整所有协变量后，油酸水平每增加1mmol/L，抑郁症患病率增加了40%(未调整OR:1.35,95CI:1.16-1.57;调整OR:1.40,95%CI:1.03-1.90).
结论：我们的研究表明油酸可能在抑郁症中起作用。需要进一步的研究来研究改变油酸水平对治疗和预防抑郁症的潜在益处。
