{Reference Type}: Journal Article
{Title}: Association of serum oleic acid level with depression in American adults: a cross-sectional study.
{Author}: Yin J;Li S;Li J;Gong R;Jia Z;Liu J;Jin Z;Yang J;Liu Y;
{Journal}: BMC Psychiatry
{Volume}: 23
{Issue}: 1
{Year}: 2023 11 16
{Factor}: 4.144
{DOI}: 10.1186/s12888-023-05271-0
{Abstract}: As the most abundant fatty acid in plasma, oleic acid has been found to be associated with multiple neurological diseases; however, results from studies of the relationship between oleic acid and depression are inconsistent.<BR>This cross-sectional study analyzed 4,459 adults from the National Health and Nutrition Examination Survey 2011-2014. The following covariates were adjusted in multivariable logistic regression models: age, sex, race/ethnicity, education level, marital status, body mass index, physical activity, smoking status, alcohol status, metabolic syndrome, omega-3 polyunsaturated fatty acids, and total cholesterol.<BR>Serum oleic acid levels were positively associated with depression. After adjusting for all covariates, for every 1 mmol/L increase in oleic acid levels, the prevalence of depression increased by 40% (unadjusted OR: 1.35, 95%CI: 1.16-1.57; adjusted OR: 1.40, 95% CI: 1.03-1.90).<BR>Our study suggests that oleic acid may play a role in depression. Further research is needed to investigate the potential benefits of changing oleic acid levels for the treatment and prevention of depression.