目的:眼睑先天性黑素细胞痣(PCMN)是一种罕见的影响眼睑的先天性皮肤病变,可导致美容和心理问题以及潜在的健康风险,例如恶性肿瘤。几位作者分析了治疗PCMN的治疗策略。然而,文献中没有达成共识。本系统综述旨在评估有效性,安全,以及PCMN治疗的成功。
方法:我们在2022年10月至2023年4月期间遵循PRISMA指南进行了系统评价。我们纳入了描述或比较PCMN治疗和干预措施的所有类型的研究设计,以及组织学,复发,不良事件,患者满意度,恶性转化。搜索策略基于通过以下数据库的特定搜索词:PubMed,Embase,拉丁美洲和加勒比健康科学文献(丁香花),WebofScience,还有Scopus.包括正在进行的研究和灰色文献研究。
结果:我们分析了148名参与者的25例病例报告。的有效性,成功,对PCMN的各种治疗方法的满意度取决于具体的治疗方法和个体患者的情况。
结论:大多数研究表明,外科手术(切除)能够治疗眼睑中的PCMN。结果的可变性强调了进一步研究的重要性,以更好地了解治疗先天性黑素细胞痣的最有效和最安全的方法。
OBJECTIVE: Palpebral congenital melanocytic nevi (PCMN) is a rare congenital skin lesion affecting the eyelids that can lead to cosmetic and psychological concerns and potential health risks such as malignancy. Several authors have analyzed therapeutical strategies to treat PCMN. However, there was no consensus in the literature. This systematic
review aimed to evaluate the effectiveness, safety, and success of treatments of PCMN.
METHODS: We conducted a systematic
review following PRISMA guidelines from October 2022 to April 2023. We included all types of study designs that described or compared PCMN treatments and interventions, as well as histology, recurrence, adverse events, patient satisfaction, and malignant transformation. The search strategy was based on specific search words through the following databases: PubMed, Embase, Latin American and Caribbean Health Sciences Literature (Lilacs), Web of Science, and Scopus. Ongoing studies and gray literature studies were included.
RESULTS: We analyzed 25 case reports with 148 participants. The effectiveness, success, and satisfaction with various treatments for PCMN depend on the specific treatment method and the individual patient\'s case.
CONCLUSIONS: Most of the studies showed that surgical procedures (exeresis) are able to treat PCMN in the eyelid. The variability in outcomes emphasizes the importance of further research to better understand the most effective and safe approaches for treating congenital melanocytic nevi.