PDF(Pubmed)
Abstract：
Introduction: Melanoma, a malignant tumor arising from uncontrolled melanocytic proliferation, commonly found in the skin but capable of affecting extracutaneous sites, ranks fifth among diagnosed oncological entities and is a significant cause of cancer deaths, constituting over 80% of skin cancer mortality. Genetic factors and ultraviolet radiation (UVR) exposure, from both natural and artificial sources, are the primary risk factors. Case Presentation: We reported the case of a 25-year-old female with numerous pigmented nevi and notable changes attributed to extensive indoor tanning sessions. Dermatological examinations and dermoscopic evaluations revealed atypical features in two pigmented nevi, leading to surgical excision. Histopathological and immunohistochemical analyses confirmed a compound nevus in one lesion and superficial spreading melanoma in the other, emphasizing the importance of vigilant follow-up and the correct use of immunohistochemistry. Discussion: Indoor tanning significantly elevates the cutaneous melanoma risk, with initiation before age 35 amplifying the risk by up to 75%, especially in young women. The risk escalates with cumulative sessions, particularly exceeding 480, and individuals undergoing over 30 sessions face a 32% higher risk. UVR induces DNA damage, genetic mutations, and immunosuppression, contributing to oncogenesis. Genetic factors, like the PTCHD2 gene, may influence the tanning dependency. Legislation targeting minors has been enacted globally but only with partial efficacy. Tanning accelerators, though associated with minor side effects, correlate with high-risk behaviors. The case underscores the urgency of addressing indoor tanning risks, emphasizing targeted awareness efforts and legislative improvements. Conclusions: In conclusion, the reported case highlights the increased risk of cutaneous melanoma linked to indoor tanning, particularly among young women and specific sociodemographic groups. Despite legislative measures, challenges persist, suggesting the potential efficacy of online campaigns involving relatable influencers to raise awareness and discourage artificial tanning.
摘要：
简介:黑色素瘤,由不受控制的黑素细胞增殖引起的恶性肿瘤，常见于皮肤，但能够影响皮肤外部位，在诊断的肿瘤实体中排名第五，是癌症死亡的重要原因，占皮肤癌死亡率的80%以上。遗传因素和紫外线辐射（UVR）暴露，来自自然和人工来源，是主要的风险因素。病例介绍：我们报道了一名25岁女性的病例，该女性患有许多色素痣，并且由于广泛的室内晒黑而发生了显着变化。皮肤病学检查和皮肤镜评估显示两个色素痣的非典型特征，导致手术切除。组织病理学和免疫组织化学分析证实了一个病灶中的复合痣和另一个病灶中的浅表扩散黑色素瘤，强调警惕随访和正确使用免疫组织化学的重要性。讨论：室内晒黑显着提高皮肤黑色素瘤的风险，在35岁之前开始将风险放大高达75%，尤其是年轻女性。风险随着会议的累积而升级，特别是超过480人，经历30次以上的个人面临32%的风险。UVR诱导DNA损伤，基因突变,和免疫抑制，有助于肿瘤发生。遗传因素,就像PTCHD2基因一样，可能会影响晒黑的依赖性。针对未成年人的立法已在全球范围内颁布，但仅具有部分效力。鞣制促进剂,虽然伴随着轻微的副作用，与高风险行为相关。此案突显了解决室内晒黑风险的紧迫性,强调有针对性的提高认识工作和立法改进。结论：总之，报道的病例强调了与室内晒黑相关的皮肤黑色素瘤风险增加，特别是在年轻女性和特定的社会人口群体中。尽管采取了立法措施，挑战依然存在,建议涉及相关影响者的在线活动的潜在功效，以提高认识并阻止人工晒黑。
