■目前对高级糖基化终产物(AGEs)和认知功能的研究有限。
■我们旨在研究血浆多个AGEs与认知功能和轻度认知障碍(MCI)之间的关系。
■来自中国广场舞者生活方式和健康衰老研究的基线数据用于本横断面研究。采用超高效液相色谱-串联质谱法测定血浆羧甲基赖氨酸(CML)水平,羧乙基赖氨酸(CEL),和甲基咪唑啉酮(MG-H1)。使用四个认知测试来获得四个认知领域得分和复合z得分。Petersen标准用于诊断MCI。采用多变量线性和logistic回归模型对数据进行分析。
■这项研究包括1,018名参与者(中位年龄61.0岁,87.3%女性)。经过多变量调整后,与最低四分位数相比,CML和CEL的最高四分位数的βs分别为-0.28(-0.38,-0.17)和-0.13(-0.23,-0.03),分别,对于复合z得分。对于四个认知领域,CML与记忆呈负相关,注意,和执行功能,CEL与记忆和语言功能呈负相关。此外,较高的CML与较高的MCI几率相关.MG-H1与认知功能无关。
■高血浆AGE水平与认知功能较差相关,特别是CML和CEL,较高的CML水平也与较高的MCI几率相关.为了阐明不同AGEs对认知功能的影响及其潜在机制,需要进一步的纵向和实验研究。
UNASSIGNED: The current research on advanced glycosylation end products (AGEs) and cognitive function is limited.
UNASSIGNED: We aimed to investigate the relationship between multiple plasma AGEs and cognitive function and mild cognitive impairment (MCI).
UNASSIGNED: Baseline data from The Lifestyle and Healthy Aging of Chinese Square Dancer
Study was used in this cross-sectional
study. Ultra-high-performance liquid chromatography tandem mass spectrometry was used to determine plasma levels of carboxymethyl
lysine (CML), carboxyethyl
lysine (CEL), and methyl imidazolinone (MG-H1). Four cognitive tests were used to obtain the four cognitive domain scores and the composite z scores. The Petersen criteria were used to diagnose MCI. The data were analyzed by multivariable linear and logistic regression models.
UNASSIGNED: This
study included 1,018 participants (median age 61.0 years, 87.3% female). After multivariate adjustment, the βs of the highest quartile of CML and CEL compared to the lowest quartile were -0.28 (-0.38, -0.17) and -0.13 (-0.23, -0.03), respectively, for the composite z score. For the four cognitive domains, CML was negatively correlated with memory, attention, and executive function, and CEL was negatively associated with memory and language function. In addition, higher CML was associated with a higher odds of MCI. MG-H1 was not associated with cognitive function.
UNASSIGNED: High plasma AGE levels were correlated with poorer cognitive function, particularly CML and CEL, higher levels of CML were also associated with higher odds of MCI. To clarify the effects of different AGEs on cognitive function and the underlying mechanisms, further longitudinal and experimental studies are needed.