PDF(Pubmed)
Abstract：
Gastric cancer ranks as one of the most prevalent cancers worldwide. While the incidence of gastric cancer in Western countries has notably diminished over the past century, it continues to be a leading cause of cancer‑related mortality on a global scale. The majority of gastric cancers in humans are attributed to chronic Helicobacter pylori infection and the progression of gastric cancer is often preceded by gastritis, atrophy, metaplasia and dysplasia. However, the precise mechanisms underlying the development of gastric cancer remain ambiguous, including the formation of gastric polyps and precancerous lesions. In humans, two types of precancerous metaplasia have been identified in relation to gastric malignancies: Intestinal metaplasia and spasmolytic polypeptide‑expressing metaplasia (SPEM). The role of SPEM in the induction of gastric cancer has gained recent attention and its link with early‑stage human gastric cancer is increasingly evident. To gain insight into SPEM, the present study reviewed the role and research progress of SPEM in gastric cancer.
摘要：
胃癌是全球最普遍的癌症之一。尽管在过去的一个世纪中，西方国家的胃癌发病率显着下降，它仍然是全球范围内癌症相关死亡率的主要原因。人类的大多数胃癌归因于慢性幽门螺杆菌感染，胃癌的进展通常先于胃炎，萎缩,化生和发育不良。然而,胃癌发展的确切机制仍然模棱两可，包括胃息肉和癌前病变的形成。在人类中,已经确定了两种类型的癌前化生与胃恶性肿瘤有关：肠上化生和表达痉挛多肽的上化生（SPEM）。SPEM在诱导胃癌中的作用最近受到关注，其与早期人类胃癌的联系越来越明显。为了深入了解SPEM，现就SPEM在胃癌中的作用及研究进展作一综述。
