蜂蜜不等同于糖,具有全球健康促进作用,如抗氧化剂,抗菌,抗炎,和肝保护活动。然而,蜂蜜对高脂饮食诱导的慢性肾脏病(CKD)和肠道菌群的潜在影响仍有待探索.本文采用高脂饮食诱导小鼠CKD模型,对肝脏进行了分析,肾,脾脏指数,组织形态学,生化参数,CKD相关基因,和肠道微生物多样性。结果表明,蜂蜜治疗对高脂饮食引起的小鼠肾损伤具有明显的抑制作用,并改善了疾病症状。血清TC也有显著变化,TG,UA,和BUN以及肾组织中炎症相关蛋白TNF-α和IL-6水平。基因表达分析显示,蜂蜜摄入量与肠道微生物多样性密切相关。可以调节肠道微生物群的组成,增加微生物多样性,特别是双歧杆菌和S24_7,并促进短链脂肪酸(SCFA)的合成。总之,这项研究表明,蜂蜜对CKD具有预防和治疗作用,这可能与其改善微生物组成的能力有关,增加微生物多样性,并调节SCFA水平。
Honey is not equivalent to sugar and possess a worldwide health promoting effects such as antioxidant, antibacterial, anti-inflammatory, and hepatoprotective activities. Nevertheless, the potential impacts of honey on high-fat diet induced chronic kidney disease (CKD) and gut microbiota remain to be explored. Herein a high-fat diet was used to induce a mouse CKD model, and analysis was conducted on liver, kidney, spleen indices, tissue morphology, biochemical parameters, CKD related genes, and gut microbial diversity. The results indicated that significant inhibitory effects on renal damage caused by a high-fat diet in mice and improvement in disease symptoms were observed upon honey treatment. Significant changes were also found in serum TC, TG, UA, and BUN as well as the inflammation-related protein TNF-α and IL-6 levels in renal tissues. Gene expression analysis revealed that honey intake closely relates to gut microbiota diversity, which can regulate the composition of gut microbiota, increase microbial diversity, especially Bifidobacteriales and S24_7 and promote the synthesis of short chain fatty acids (SCFAs). In summary, this study suggests that honey has both preventive and therapeutic effects on CKD, which may be associated with its ability to improve microbial composition, increase microbial diversity, and regulate SCFAs levels.