PDF(Pubmed)
Abstract：
Chronic stress (CS) endangers the physical and mental health of adolescents. Therefore, alleviating and preventing such negative health impacts are a top priority. This study explores the effect of feeding shrimp head hydrolysate (SHH) on gut microbiota, short-chain fatty acids (SCFAs), and neurotransmitters in growing C57BL/6 mice subjected to chronic unpredictable mild stress. Mice in the model group and three SHH groups were exposed to CS for 44 days, distilled water and SHH doses of 0.18, 0.45, 0.90 g/kg·BW were given respectively by gavage daily for 30 days from the 15th day. The results showed that SHH can significantly reverse depression-like behaviour, amino acids degradation, α diversity and β diversity, proportion of Firmicutes and Bacteroidota, abundance of genera such as Muribaculaceae, Bacteroides, Prevotellaceae_UCG-001, Parabacteroides and Alistipes, concentration of five short-chain fatty acids (SCFAs), 5-HT and glutamate induced by CS. Muribaculaceae and butyric acid may be a controlled target. This study highlights the potential and broad application of SHH as an active ingredient in food to combat chronic stress damage.
摘要：
慢性应激（CS）危害青少年的身心健康。因此,减轻和预防这种负面健康影响是当务之急。本研究探讨了饲喂虾头水解物（SHH）对肠道菌群的影响，短链脂肪酸（SCFA），和神经递质生长中的C57BL/6小鼠受到慢性不可预测的轻度应激。模型组和三个SHH组的小鼠暴露于CS44天，从第15天起，每天灌胃30天，分别给予蒸馏水和SHH剂量为0.18、0.45、0.90g/kg·BW。结果表明，SHH可以显著逆转抑郁样行为，氨基酸降解，α多样性和β多样性，Firmicutes和拟杆菌的比例，丰富的属，如Muribaculaceae，拟杆菌,Prevotellaceae_UCG-001，副杆菌属和Alistipes，五种短链脂肪酸(SCFA)的浓度，CS诱导的5-HT和谷氨酸。Muribaculaceae和丁酸可能是受控目标。这项研究强调了SHH作为食品中活性成分对抗慢性应激损伤的潜在和广泛应用。
