PDF(Pubmed)
Abstract：
In recent years, a growing body of research has confirmed that the gut microbiota plays a major role in the maintenance of human health and disease. A gut microbiota imbalance can lead to the development of many diseases, such as pregnancy complications, adverse pregnancy outcomes, polycystic ovary syndrome, endometriosis, and cancer. Short-chain fatty acids are metabolites of specific intestinal bacteria and are crucial for maintaining intestinal homeostasis and regulating metabolism and immunity. Endometriosis is the result of cell proliferation, escape from immune surveillance, and invasive metastasis. There is a strong correlation between the anti-proliferative and anti-inflammatory effects of short-chain fatty acids produced by gut microbes and the development of endometriosis. Given that the mechanism of action of gut microbiota and Short-chain fatty acids in endometriosis remain unclear, this paper aims to provide a comprehensive review of the complex interactions between intestinal flora, short-chain fatty acids and endometriosis. In addition, we explored potential microbial-based treatment strategies for endometriosis, providing new insights into the future development of diagnostic tests and prevention and treatment methods for endometriosis.
摘要：
近年来,越来越多的研究证实，肠道菌群在维持人类健康和疾病方面发挥着重要作用。肠道微生物群失衡可导致许多疾病的发展，如妊娠并发症，不良妊娠结局,多囊卵巢综合征,子宫内膜异位症,和癌症。短链脂肪酸是特定肠道细菌的代谢产物，对于维持肠道稳态以及调节代谢和免疫力至关重要。子宫内膜异位症是细胞增殖的结果，逃避免疫监视，和侵袭性转移。肠道微生物产生的短链脂肪酸的抗增殖和抗炎作用与子宫内膜异位症的发展之间存在很强的相关性。鉴于肠道菌群和短链脂肪酸在子宫内膜异位症中的作用机制尚不清楚，本文旨在全面综述肠道菌群之间的复杂相互作用，短链脂肪酸和子宫内膜异位症。此外,我们探讨了子宫内膜异位症的潜在微生物治疗策略，为子宫内膜异位症的诊断和预防治疗方法的未来发展提供新的见解。
