背景:最近报道了红细胞分布宽度(RDW)和D-二聚体作为某些血液恶性肿瘤患者的预后因素的重要作用。
目的:我们设计并进行了一项荟萃分析,以研究RDW和D-Dimer在弥漫性大B细胞淋巴瘤(DLBCL)患者中的预后作用。
方法:我们系统回顾了PubMed-Medline,Scopus,EMBASE,WebofScience核心合集,和谷歌学者到目前为止,寻找有关RDW和D-二聚体对DLBCL患者预后影响的出版物。为了研究RDW和D-Dimer与DLBCL病例的总生存期(OS)和无进展生存期(PFS)之间的关系,使用风险比(HR)和95%置信区间(CIs).
结果:我们在本荟萃分析中纳入了13项符合条件的研究。合并分析结果显示,在DLBCL患者中,RDW水平的升高与OS差(HR=2.01,95%CI:1.62-2.48,p值<.01,I2=0%)和PFS差(HR=1.52,95%CI:1.24-1.85,p值<.01,I2=16%)有关。同样,在DLBCL患者中,D-Dimer升高与OS差(HR=2.30,95%CI:1.03-5.14,p值<.05,I2=95%)之间也存在显著关系。此外,在纳入meta分析的研究中,与RDW相关的OS(p值H=0.65)和PFS(p值H=0.31)没有显著异质性.
结论:我们的发现清楚地证实,RDW水平和D-二聚体升高与DLBCL不良OS和PFS相关。
The significant role of red blood cell distribution width (RDW) and D-Dimer as prognostic factors in patients with some blood malignancies has been reported recently.
We designed and performed a meta-analysis to investigate the prognostic roles of RDW and D-Dimer in subjects with diffuse large B-cell lymphoma (DLBCL).
We systematically reviewed PubMed-Medline, SCOPUS, EMBASE, Web of Science Core Collection, and Google Scholar up to the present to look for publications on prognostic effects of RDW and D-Dimer in DLBCL patients. For investigation of the associations between RDW and D-Dimer with the overall survival (OS) and progression-free survival (PFS) of the DLBCL cases, hazard ratio (HR) with 95% confidence intervals (CIs) was used.
We included 13 eligible studies in the present meta-analysis. The results of pooled analysis showed that increased levels of RDW was related to poor OS (HR = 2.01, 95% CI: 1.62-2.48, p value <.01, I2 = 0%) and poor PFS (HR = 1.52, 95% CI: 1.24-1.85, p value <.01, I2 = 16%) among the DLBCL patients. Similarly, a significant relationship was found between increased D-Dimer and poor OS (HR = 2.30, 95% CI: 1.03-5.14, p value <.05, I2 = 95%) of the DLBCL patients as well. In addition, there was no significant heterogeneity in OS (p value H = 0.65) and PFS (p value H = 0.31) related to RDW among studies included in the meta-analysis.
Our finding clearly confirmed that elevated RDW levels and D-Dimer were associated with adverse OS and PFS in DLBCL.