PubMed, CENTRAL, Scopus, Web of Science, and Embase were searched up to 10th January 2023 for studies comparing mortality after hip fracture based on RDW. All cut-offs of RDW were accepted. Crude and adjusted mortality ratios were pooled separately.
Nine studies with 5,274 patients were eligible. Meta-analysis of eight studies reporting crude mortality rates showed that patients with high RDW had a significantly higher risk of mortality than those with low RDW (RR: 2.81 95% CI: 2.05, 3.86 I2=82%). The results did not change in significance on subgroup analyses based on study location, sample size, the cut-off of RDW, and follow-up. Four studies reported adjusted mortality rates. Analysis of the same showed that high RDW was an independent predictor of mortality in hip fracture patients (HR: 3.14 95% CI: 1.38, 7.14 I2=95%).
Within the limitations of the review, RDW was found to be an indicator of mortality in hip fracture patients. High RDW was significantly associated with increased mortality despite different cut-offs among studies. Further research is needed to generate more rigorous evidence.
方法:PubMed,中部,Scopus,WebofScience,和Embase在2023年1月10日之前进行了基于RDW的髋部骨折后死亡率比较研究.RDW的所有截止日期均被接受。粗死亡率和调整后的死亡率分别汇总。
结果:符合资格的有5,274名患者的9项研究。对8项报告粗死亡率的研究的荟萃分析表明,高RDW患者的死亡风险明显高于低RDW患者(RR:2.8195%CI:2.05,3.86I2=82%)。基于研究地点的亚组分析结果的显著性没有变化,样本量,RDW的截止,和后续行动。四项研究报告了调整后的死亡率。同样的分析表明,高RDW是髋部骨折患者死亡率的独立预测因子(HR:3.1495%CI:1.38,7.14I2=95%)。
结论:在审查的限制范围内,发现RDW是髋部骨折患者死亡率的指标。尽管研究之间存在不同的界限,但高RDW与死亡率增加显着相关。需要进一步的研究来产生更严格的证据。