Abstract：
This review examined the association between red cell distribution width (RDW) and mortality after hip fracture.
PubMed, CENTRAL, Scopus, Web of Science, and Embase were searched up to 10th January 2023 for studies comparing mortality after hip fracture based on RDW. All cut-offs of RDW were accepted. Crude and adjusted mortality ratios were pooled separately.
Nine studies with 5,274 patients were eligible. Meta-analysis of eight studies reporting crude mortality rates showed that patients with high RDW had a significantly higher risk of mortality than those with low RDW (RR: 2.81 95% CI: 2.05, 3.86 I2=82%). The results did not change in significance on subgroup analyses based on study location, sample size, the cut-off of RDW, and follow-up. Four studies reported adjusted mortality rates. Analysis of the same showed that high RDW was an independent predictor of mortality in hip fracture patients (HR: 3.14 95% CI: 1.38, 7.14 I2=95%).
Within the limitations of the review, RDW was found to be an indicator of mortality in hip fracture patients. High RDW was significantly associated with increased mortality despite different cut-offs among studies. Further research is needed to generate more rigorous evidence.
PubMed, CENTRAL, Scopus, Web of Science, and Embase were searched up to 10th January 2023 for studies comparing mortality after hip fracture based on RDW. All cut-offs of RDW were accepted. Crude and adjusted mortality ratios were pooled separately.
Nine studies with 5,274 patients were eligible. Meta-analysis of eight studies reporting crude mortality rates showed that patients with high RDW had a significantly higher risk of mortality than those with low RDW (RR: 2.81 95% CI: 2.05, 3.86 I2=82%). The results did not change in significance on subgroup analyses based on study location, sample size, the cut-off of RDW, and follow-up. Four studies reported adjusted mortality rates. Analysis of the same showed that high RDW was an independent predictor of mortality in hip fracture patients (HR: 3.14 95% CI: 1.38, 7.14 I2=95%).
Within the limitations of the review, RDW was found to be an indicator of mortality in hip fracture patients. High RDW was significantly associated with increased mortality despite different cut-offs among studies. Further research is needed to generate more rigorous evidence.
摘要：
目的：这篇综述探讨了红细胞分布宽度（RDW）与髋部骨折后死亡率之间的关系。
方法：PubMed，中部,Scopus,WebofScience,和Embase在2023年1月10日之前进行了基于RDW的髋部骨折后死亡率比较研究.RDW的所有截止日期均被接受。粗死亡率和调整后的死亡率分别汇总。
结果：符合资格的有5,274名患者的9项研究。对8项报告粗死亡率的研究的荟萃分析表明，高RDW患者的死亡风险明显高于低RDW患者（RR：2.8195％CI：2.05，3.86I2=82％）。基于研究地点的亚组分析结果的显著性没有变化，样本量,RDW的截止，和后续行动。四项研究报告了调整后的死亡率。同样的分析表明，高RDW是髋部骨折患者死亡率的独立预测因子（HR：3.1495％CI：1.38，7.14I2=95％）。
结论：在审查的限制范围内，发现RDW是髋部骨折患者死亡率的指标。尽管研究之间存在不同的界限，但高RDW与死亡率增加显着相关。需要进一步的研究来产生更严格的证据。
方法：PubMed，中部,Scopus,WebofScience,和Embase在2023年1月10日之前进行了基于RDW的髋部骨折后死亡率比较研究.RDW的所有截止日期均被接受。粗死亡率和调整后的死亡率分别汇总。
结果：符合资格的有5,274名患者的9项研究。对8项报告粗死亡率的研究的荟萃分析表明，高RDW患者的死亡风险明显高于低RDW患者（RR：2.8195％CI：2.05，3.86I2=82％）。基于研究地点的亚组分析结果的显著性没有变化，样本量,RDW的截止，和后续行动。四项研究报告了调整后的死亡率。同样的分析表明，高RDW是髋部骨折患者死亡率的独立预测因子（HR：3.1495％CI：1.38，7.14I2=95％）。
结论：在审查的限制范围内，发现RDW是髋部骨折患者死亡率的指标。尽管研究之间存在不同的界限，但高RDW与死亡率增加显着相关。需要进一步的研究来产生更严格的证据。
