Abstract：
No definitive prognostic biomarkers for carbon monoxide (CO) poisoning have been proposed. The aim of this study is to investigate, through a systematic literature review and pooled analysis, whether red blood cell distribution width (RDW) can predict disease severity in CO-poisoned patients. We performed an electronic search in Scopus and PubMed using the keywords: \'red blood cell distribution width\' OR \'RDW\' AND \'carbon monoxide\' AND \'poisoning,\' with no time or language restrictions (i.e. through August 2023) to find clinical studies that examined the value of RDW in patients with varying severity of CO poisoning. The analysis was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 reporting checklist. We identified 29 articles, seven of which were included in our analysis, with a total of 1979 CO-poisoned patients, 25.9% of whom were severely ill. In all but one of the studies, the RWD mean or median value was higher in CO-poisoned patients with severe disease. The weighted mean difference (WMD) of RDW was 0.36 (95% confidence interval (CI), 0.26-0.47)%. In the three articles in which the severity of illness in CO-poisoned patients was defined as cardiac injury, the WMD of the RDW was 1.26 (95%CI, 1.02-1.50)%. These results suggest that monitoring RDW in CO-poisoned patients may help to determine the severity of disease, particularly cardiac injury.
摘要：
尚未提出一氧化碳（CO）中毒的明确预后生物标志物。本研究的目的是调查,通过系统的文献回顾和汇总分析，红细胞分布宽度（RDW）是否可以预测CO中毒患者的疾病严重程度。我们在Scopus和PubMed中使用关键字进行了电子搜索：\'红细胞分布宽度\'或\'RDW\'和\'一氧化碳\'和\'中毒，\'没有时间或语言限制（即到2023年8月），以找到临床研究，检查RDW在不同严重程度的CO中毒患者中的价值。根据PRISMA（系统审查和荟萃分析的首选报告项目）2020报告清单进行分析。我们确定了29篇文章，其中七个被包括在我们的分析中，共有1979名一氧化碳中毒患者，其中25.9%病重。除了一项研究，重度CO中毒患者的RWD均值或中位值较高.RDW的加权平均差(WMD)为0.36(95%置信区间(CI)，0.26-0.47)%。在将CO中毒患者的疾病严重程度定义为心脏损伤的三篇文章中，RDW的WMD为1.26(95CI,1.02-1.50)%。这些结果表明，监测CO中毒患者的RDW可能有助于确定疾病的严重程度，尤其是心脏损伤。
