Abstract：
Diseases of the aorta, such as aortic aneurysm, dissection, and rupture, account for a large proportion of acute clinical emergencies. The red blood cell distribution width (RDW), which directly reflects anisocytosis (i.e., the heterogeneity of erythrocyte volumes), has emerged as a promising biomarker for many cardiovascular pathologies. Thus, we aimed to explore the implication of RDW in aortic pathologies. We searched Scopus and PubMed using the keywords \"RDW\" OR \"red blood cell distribution width\" AND \"aortic aneurysm\" OR \"aortic dilatation\" OR \"aortic dissection\" for identifying studies in which RDW values were measured in patients with these aortic diseases. Ten observational studies were finally included. In all studies, RDW value was increased in patients with aortic diseases. In the four studies in which sufficient RDW data were available for pooling, the weighted mean difference (WMD) of RDW in patients with or without complicated aortic pathologies was 0.575 (95 %CI, 0.254-0.896). RDW may be a valuable diagnostic and prognostic biomarker in patients with aortic pathologies.
摘要：
主动脉疾病,比如主动脉瘤,解剖,和破裂，在临床急症中占很大比例。红细胞分布宽度(RDW),这直接反映了红细胞增多症(即，红细胞体积的异质性)，已经成为许多心血管疾病的有希望的生物标志物。因此，我们旨在探讨RDW在主动脉病变中的意义。我们使用关键字\"RDW\"或\"红细胞分布宽度\"和\"主动脉瘤\"或\"主动脉扩张\"或\"主动脉夹层\"搜索Scopus和PubMed，以确定在这些主动脉疾病患者中测量RDW值的研究。最终纳入了10项观察性研究。在所有研究中,主动脉疾病患者的RDW值升高。在有足够的RDW数据可用于汇集的四项研究中，在有或无复杂主动脉病变的患者中,RDW的加权平均差值(WMD)为0.575(95CI,0.254~0.896).RDW可能是主动脉病变患者的有价值的诊断和预后生物标志物。
